Pharmaceutical Suspensions: From Formulation Development to Manufacturing

Pharmaceutical Suspensions: From Formulation Development to Manufacturing.

By Alok K. Kulshreshtha, Onkar N. Singh, G. Michael Wall

• Publisher: Springer
• Number Of Pages: 323
• Publication Date: 2009-10-16
• ISBN-10 / ASIN: 1441910867
• ISBN-13 / EAN: 9781441910868

Product Description:

The suspension dosage form has long been used for poorly soluble active ingredients for various therapeutic indications. Development of stable dispersions over the shelf life of the drug product continues to be a challenge on many fronts.

A good understanding of fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of suspension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, viscometers, particle size analyzers, etc.) must be utilized to properly characterize the suspension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require clinical trials to establish the safety and efficacy of the drug product. All of this development work should culminate into a regulatory filing in accordance with regulatory guidelines. Pharmaceutical Suspensions, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical active dispersed in a suitable vehicle.

After discussing various disperse systems, the theory of disperse systems and commonly used excipients, the remaining chapters in this textbook systematically detail the development of pharmaceutical suspensions, from pre-formulation stage to clinical development, regulatory submission and commercial manufacturing. Additionally, the emerging area of nano-suspensions as applied to pharmaceutical filed is also discussed. Each of the chapters in Pharmaceutical Suspensions was written independently by scientists skilled in their specific areas. Contributing authors represent a cross-sections of scholars from Academic Institutions, Pharmaceutical Industries and Regulatory Agency.

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Polymorphism in Pharmaceutical Solids, Second Edition (Drugs and the Pharmaceutical Sciences)

Polymorphism in Pharmaceutical Solids, Second Edition (Drugs and the Pharmaceutical Sciences).

By Harry G. Brittain

• Publisher: Informa Healthcare
• Number Of Pages: 656
• Publication Date: 2009-07-27
• ISBN-10 / ASIN: 1420073214
• ISBN-13 / EAN: 9781420073218

Product Description:

Using clear and practical examples, Polymorphism in Pharmaceutical Solids, Second Edition presents a complete examination of polymorphic behavior in pharmaceutical development.

Ideal for pharmaceutical development scientists and graduate students in pharmaceutical science, this updated edition includes:

NEW CHAPTERS - on the latest developments and methods in the field that give pharmaceutical development scientists the up-to-date information they need to successfully implement new drug development techniques and methods

EXPERT EDITORSHIP - from Dr. Harry G. Brittain, whose vast experience and knowledge of the pharmaceutical industry provides readers with the authoritative advice they need and trust

COMPREHENSIVE CONTENT - that includes information appropriate for all levels of expertise in the field, from experienced pharmaceutical scientists to graduate students in physical pharmacy

200 HIGH QUALITY ILLUSTRATIONS - that present readers with a visual blueprint to the methods and techniques involved in polymorphism and solvatomorphism.

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Handbook of Drug Screening, Second Edition (Drugs and the Pharmaceutical Sciences) By Ramakrishna Seethala, Litao Zhang

Handbook of Drug Screening, Second Edition (Drugs and the Pharmaceutical Sciences)

By Ramakrishna Seethala, Litao Zhang.

• Publisher: Informa Healthcare
• Number Of Pages: 504
• Publication Date: 2009-06-24
• ISBN-10 / ASIN: 1420061682
• ISBN-13 / EAN: 9781420061680

Product Description:

Building upon the foundation of basics discussed in the previous edition, the Second Edition provides a more in-depth look at the latest methods and technologies of advanced drug screening, an essential function of drug discovery.

With extensively updated content and 21 new chapters, this text examines:

quality and efficiency of drug target validation and potential drug compound selection

reducing assay costs and improvement in assay technology

data quality improvement

trends in drug discovery

how drug screening can minimize adverse drug effects

recent advancements, including: high content screening; protein-protein interactions; high-throughput crystallization; lead optimization; chemoinformatics and microfluidics technologies; target validation by genomics, proteomics, and siRNA; structure-based drug design; automation; and medicinal chemistry.

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New Drug Approval Process, Fifth Edition: Global Challenges and Solutions (Drugs and the Pharmaceutical Sciences)

New Drug Approval Process, Fifth Edition: Global Challenges and Solutions (Drugs and the Pharmaceutical Sciences).

By Richard Guarino

• Publisher: Informa Healthcare
• Number Of Pages: 664
• Publication Date: 2009-06-24
• ISBN-10 / ASIN: 1420088491
• ISBN-13 / EAN: 9781420088496

Product Description:

Gain insight into applying research and regulatory capabilities to new pharmaceutical product approvals for increased efficiency and speed to market.

STEP-BY-STEP GUIDELINES on developing and submitting the research and documentation that worldwide agencies require for product approval helps minimize errors and saves valuable time

CONTRIBUTIONS FROM 20 INTERNATIONAL THOUGHT LEADERS provides practical approaches to resolving problems that might occur during product development, with the full benefit of their years of successes and failures

UPDATES ON GLOBAL CHALLENGES that affect bringing new pharmaceutical products to market and changes that will have a tremendous influence on how new products are researched and marketed offers valuable advice to all who are involved in the drug development process.

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Precision Crystallization: Theory and Practice of Controlling Crystal Size By Ingo Leubner

Precision Crystallization: Theory and Practice of Controlling Crystal Size

By Ingo Leubner.

• Publisher: CRC
• Number Of Pages: 216
• Publication Date: 2009-09-28
• ISBN-10 / ASIN: 1439806748
• ISBN-13 / EAN: 9781439806746

Product Description:

Despite the fact that crystals make up an estimated 80% of chemical and pharmaceutical products, few resources exist that provide practical guidance on achieving precision control of their size and size distribution. Based on a model developed by the author and his colleagues, Precision Crystallization: Theory and Practice of Controlling Crystal Size presents scientists and product engineers with the tools to control crystal nucleation, enabling them to ultimately control crystal size and size distribution for batch and continuous crystallizations.

At the cutting edge of crystallization science and technology, this volume presents information never before available. Introducing the Balanced Nucleation and Growth (BNG) model, the book demonstrates how the results of the nucleation process are quantitatively related to practical experimental control values such as.

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Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability (Methods and Principles in Medicinal Chemistry)

Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability (Methods and Principles in Medicinal Chemistry).

By Han van de Waterbeemd, Bernard Testa, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

• Publisher: Wiley-VCH
• Number Of Pages: 649
• Publication Date: 2008-12-15
• ISBN-10 / ASIN: 3527320512
• ISBN-13 / EAN: 9783527320516

Product Description

The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten.

In 21 chapters readers can benefit from the key working knowledge of today′s leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the factors governing drug bioavailability, complete with practical examples and real–life data.

Part I focuses on in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and ionization. Part II discusses solubility and gastrointestinal absorption, while the third part is devoted to metabolism and excretory mechanisms. The much revised and expanded part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows how poor bioavailability may be improved by various approaches during the development process.

No other publication offers the same level of treatment on this crucial topic in modern drug development.

From the Back Cover In order to reach its intended site of action, the drug molecules in every pill that we swallow must first be absorbed, transported via the bloodstream and evade various mechanisms that eliminate drugs from the body. Those drug properties that determine, for example, its stability in the gut or its ease of uptake into the bloodstream, are therefore of central importance in drug development. In fact, many potentially useful drugs fail because of insufficient availability at the biological target site.

This second edition of the gold standard for industrial research is thoroughly revised in line with current trends in the field, with all contributions extensively updated or rewritten. No other publication offers the same level of treatment on this crucial topic.

In 22 chapters readers can benefit from the key working knowledge of today′s leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the factors governing drug bioavailability, complete with practical examples and real–life data.

Part I focuses on solubility and gastrointestinal absorption, while the second discusses in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and solubility. Part III is devoted to metabolism and excretory mechanisms. The much revised and expanded Part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows new drug development approaches as well as delivery strategies.

Indispensable for all those working in the pharmaceutical industry, pharmaceutical and medicinal chemists, and toxicologists.

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L.E. Smart, "Separation, Purification and Identification"

: 0

L.E. Smart, "Separation, Purification and Identification".

Royal Society of Chemistry; 1 edition (August 12, 2002) | English | 0854046866 | 120 pages | PDF | 17.15 MB

This book looks at the common techniques used to prepare, purify and indentify chemicals. Topics including distillation, recrystallisation, chromatography, elemental analysis, atomic absorption spectroscopy and mass spectrometry are discussed, and are illustrated on video on the accompanying CD-ROMs. Infrared and nuclear magnetic resonance spectroscopy are covered entirely through multi-media, with animations and virtual experiments. The reader is provided with examples for interpretation, and can draw in the structures using the software provided. There is also a set of interactive self-assessment questions. In all, the multi-media software suite comprises more than twelve hours of material. Separation, Purification and Identification concludes with a Case Study on Forensic Science, in which illustrations of criminal cases where spectroscopic techniques provided evidence are given. The Molecular World series provides an integrated introduction to all branches of chemistry for both students wishing to specialise and those wishing to gain a broad understanding of chemistry and its relevance to the everyday world and to other areas of science. The books, with their Case Studies and accompanying multi-media interactive CD-ROMs, will also provide valuable resource material for teachers and lecturers.

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Functional Group Chemistry

Functional Group Chemistry.

(Tutorial Chemistry Texts)

by

J. R. Hanson

Publisher

Royal Society of Chemistry

Number Of Pages: 165

Publication Date: 2001-09-30

ISBN-10 / ASIN: 0854046275

ISBN-13 / EAN: 9780854046270

Binding: Paperback

BooK Description

This work presents the chemistry of functional groups with an emphasis on patterns of reactivity, the consequences of the relative electronegativity of the atoms that constitute the functional groups, the role or lone pairs and the stereochemistry of reactions at a particular group. The material is presented in four sections. The first section considers functional groups involving C-X bonds such as alkyl halides, alcohols, ethers and amines. The second section considers unsymmetrical p=bonded C=X functional groups, typically the carbonyl group and the influence of these groups on adjacent centres. The third section covers symmetrical p-bonded functional groups including alkenes, alkynes and arenes and the consequences of the factors that perturb the symmetry, such as on the orientation of aromatic substitution. The final section concentrates on interconversions like oxidation and reduction, and the protection of functional groups to achieve selectivity. The chemistry of the functional groups is considered here with mechanistic rationale. Students will be encouraged to consider reactions in terms of regions of electron deficiency and excess, and hence identify the sites at which electrophiles and nucleophiles might react.

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Hydrogen Bonding in Organic Synthesis

Hydrogen Bonding in Organic Synthesis. By Petri M. Pihko * Publisher: Wiley-VCH * Number Of Pages: 395 * Publication Date: 2009-12-14 * ISBN-10 / ASIN: 352731895X * ISBN-13 / EAN: 9783527318957 Product Description This first comprehensive overview of the rapidly growing field emphasizes the use of hydrogen bonding as a tool for organic synthesis, especially catalysis. As such, it covers such topics as enzyme chemistry, organocatalysis and total synthesis, all unified by the unique advantages of hydrogen bonding in the construction of complex molecules from simple precursors. Providing everything you need to know, this is a definite must for every synthetic chemist in academia and industry. From the Back Cover Snow and ice, water droplets, and all key materials of life –– the double strands of DNA and all proteins –– are held together by intermolecular forces called hydrogen bonds. These bonds, although weaker than bonds within molecules, are still strong enough to chaperone molecules into desired orientations, allowing chemists to use them as tools to perform reactions with high selectivity. In addition, hydrogen bonding can lead to metal–free catalysts, thus saving chemicals and energy in an otherwise lengthy purification process while also reducing the heavy metal output in the environment. This first comprehensive overview of the rapidly growing field emphasizes the use of hydrogen bonding as a tool for organic synthesis, especially catalysis. As such, it covers such topics as enzyme chemistry, organocatalysis and total synthesis, all unified by the unique advantages of hydrogen bonding in the construction of complex molecules from simple precursors. From the contents: ? Introduction ? Hydrogen Bond Catalysis or Br?nsted Acid Catalysis? General Considerations ? Computational Studies of Organocatalytic Processes Based on Hydrogen Bonding ? Oxyanion holes and their mimics ? Br?nsted Acids, H–Bond Donors, and Combined Acid Systems in Asymmetric Catalysis ? Hydrogen Bonding in Organic Synthesis – (Thio)urea Organocatalysts ? Highlights of Hydrogen Bonding in Total Synthesis Providing everything you need to know, this is a definite must for every synthetic chemist in academia

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Chetan Bhagat: 2 States: The Story Of My Marriage

Publisher: Rupa & Co. 2009 | ISBN: 8129115301 | PDF | 291 pages | 30.9 mb

Love marriages around the world are simple:

Boy loves girl. Girl loves boy.
They get married.

In India, there are a few more steps:

Boy loves Girl. Girl loves Boy.
Girl’s family has to love boy. Boy’s family has to love girl.
Girl’s Family has to love Boy’s Family. Boy’s family has to love girl’s family.
Girl and Boy still love each other. They get married.

Welcome to 2 States, a story about Krish and Ananya. They are from two different states of India, deeply in love and want to get married. Of course, their parents don’t agree. To convert their love story into a love marriage, the couple have a tough battle in front of them. For it is easy to fight and rebel, but it is much harder to convince. Will they make it? From the author of blockbusters Five Point Someone, One Night @ the Call Center and The 3 Mistakes of My Life, comes another witty tale about inter-community marriages in modern india.

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Golden Software Grapher 8.0.278

Golden Software Grapher 8.0.278

Win App | 27.1 MB | RS.COM

An efficient and powerful graphing program for all of your most complex graphing needs. Ideal for scientists, engineers, and business professionals! Fast. Easy. Accurate.

Grapher 8 is the ultimate graphing package available! Discover how this easy-to-use, powerful, and dynamic program can help you create superior and professional graphs! With Grapher, it has never been easier to WOW your audience with the most impressive graphs, every time!

Grapher will help you present your information in a clear and precise manner. Choose from 54 different graph types to find the graph which best represents your data. Add text, draw objects, customize colors, or insert your company logo to create the perfect graph. Once you have finished installing Grapher 8, you will be creating fabulous and illustrative graphs within minutes!

Grapher’s possibilities are limited only by your imagination! Customize your graphs so they look their best! Each of Grapher’s 54 graph types has a multitude of editing options to enhance its appearance. Change line colors and thicknesses, add gradient color fills, or add solid fills and adjust the opacity to see the information below. Create informative graphs by adding error bars, fit curves, confidence intervals, titles, and legends. You can even add your own customizations to the defaults, so the default graph is truly yours! These are just some of the endless options Grapher offers to easily create the most colorful, descriptive, and understandable graphs—ready for publication!

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Portable ChemSketch 12

Portable ChemSketch 12 | 35 Mb

(with 3D viewer, ChemBasic, CHNMR viewer, User guides and Tutorial)

ACD/ChemSketch contains tools not available in some other commercial drawing packages, including tools for 2D structure cleaning, 3D optimization and viewing, InChI generation and conversion, drawing of polymers, organometallics, Markush structures, and IUPAC systematic naming capability for molecules with fewer than 50 atoms and 3 rings. Further extend and customize the capabilities of ACD/ChemSketch by programming with ChemBasic.

Portable 'ChemSketch 12' does not require installation. Make as many copies as you need. Carry it in a flash drive and use on any computer, even without administrator access. No change of any setting on the host computer. No more conflicts with other applications. No more 'hijacking' of file types. The portable app creates a sandbox folder in the current directory and stores all settings and temp files therein.

Please note that this app is the portabled version of the ChemSketch Freeware.

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Portable ScienceWord 5.0.3.1

Portable ScienceWord 5.0.3.1 | 28 Mb

Novoasoft ScienceWord 5 is a professional scientific document word processor. It combines formulae, graphics, curves, logical graphics with words perfectly. ScienceWord increases work efficiency.

The portable app does not require installation. Make as many copies as you need. Carry it in a flash drive and use on any computer, even without administrator access. No change of any setting on the host computer. No more conflicts with other applications. No more 'hijacking' of file types.

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Portable PatentHunter 3.5.16

Portable PatentHunter 3.5.16

Portable PatentHunter 3.5.16 | 17 Mb

PatentHunter is a software program that helps patent attorneys, businesses and inventors search, download and manage United States and foreign patents. Unlike commercial providers who can charge $3 to $5 per patent, downloading patents with PatentHunter is FREE because PatentHunter searches patents and downloads complete patent images from the USPTO and EPO websites. PatentHunter was created by a U.S. Patent Attorney, Michael S. Neustel of Neustel Law Offices, LTD.

The portable app does not require installation. Make as many copies as you need. Carry it in a flash drive and use on any computer, even without administrator access. No change of any setting on the host computer. No more conflicts with other applications. No more 'hijacking' of file types.

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Intellectual Property: A Reference Handbook

Intellectual Property: A Reference Handbook.

318 pages | ABC-CLIO (April 26, 2007) | 1598840452 | PDF | 1 Mb

Can you own an idea? Yes, you can. Intellectual property, a concept dating back to the Middle Ages, is today an increasingly important part of both the domestic economy and international trade. Yet today, easy access to file-sharing software via home computers and the Internet has created a new crisis in intellectual property law, which struggles to keep pace with new developments.

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David Goldberg, "Fundamentals of Chemistry"

David Goldberg, "Fundamentals of Chemistry".

Mg-H | 2006 | ISBN: 007322104X | 720 pages | PDF | 14,2 MB

Designed for the one-semester preparatory chemistry course, the new, fifth edition of Fundamentals of Chemistry provides students with a solid foundation in problem solving for all the topic areas covered in a standard general chemistry course.

The author not only provides a clear consistent methodology to help students develop conceptual and quantitative problem-solving skills, but also engages students by using analogies that relate chemistry to everyday life. Students who need help with mathematical manipulations, as well as reading and writing scientific material, will find Goldberg’s text an excellent learning tool.

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HPLC of Macromolecules: A Practical Approach by: R.W.A. Oliver

HPLC of Macromolecules: A Practical Approach by: R.W.A. Oliver.

Publisher: IRL Press | ISBN: 1852210672 | 1988-01 | Pages: 250 | DJVU | 2.8 MB

HPLC stands for high pressure (or performance) liquid chromatography, and is a standard biochemical technique for separating molecules. This volume covers the larger biomolecules - oligosaccharides, glycopeptides, oligonucleotides, polypeptides, and proteins - and includes the latest advances in microbore and packed capillary technology, and in the use of mass spectrometric detection.

Columns for HPLC separations of macromolecules

HPLC instrumentation

Size-exclusion HPLC of proteins

Ion-exchange chromatography of proteins and peptides

Reversed-phase chromatography of proteins

High Performance affinity chromatography

HPLC of oligonucleotides

Affinity chromatography of complex carbohydrates using lectins

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3000 Solved Problems in Organic Chemistry: volume 1(Re-Post)

3000 Solved Problems in Organic Chemistry: volume 1

• 
  Publisher: McGraw-Hill
• Language: English
• ISBN-10: 0070564248
• ISBN-13: 978-0070564244

Product Description

Solved Problem Series These books help readers review and master what they've learned by showing them how to solve thousands of relevant problems. Perfect for preparing for graduate or professional exams, these detailed reminders of problem-solving techniques show readers the best strategies for answering even the toughest questions, including the types that appear on typical tests.

From the Back Cover

Master organic chemistry with Schaum'sNthe high-performance solved-problem guide. It will help you cut study time, hone problem-solving skills, and achieve your personal best on exams! Students love Schaum's Solved Problem Guides because they produce results. Each year, thousands of students improve their test scores and final grades with these indispensable guides. Get the edge on your classmates. Use Schaum's! If you don't have a lot of time but want to excel in class, use this book to: Brush up before tests; Study quickly and more effectively; Learn the best strategies for solving tough problems in step-by-step detail. Review what you've learned in class by solving thousands of relevant problems that test your skill. Compatible with any classroom text, SchaumOs Solved Problem Guides let you practice at your own pace and remind you of all the important problem-solving techniques you need to rememberNfast! And SchaumOs are so complete, theyOre perfect for preparing for graduate or professional exams. I nside you will find: 3000 solved problems with complete solutionsNthe largest selection of solved problems yet published on this subject; An index to help you quickly locate the types of problems you want to solve; Problems like those you'll find on your exams; Techniques for choosing the correct approach to problems; Guidance toward the quickest, most efficient solutions. If you want top grades and thorough understanding of organic chemistry, this powerful study tool is the best tutor you can have! Chapters include: Structure and Properties. Bonding and Molecular Structure. Chemical Reactivity and Organic Reactions. Alkanes. Cycloalkanes. Stereochemistry. Alkenes. Alkyl Halides. Alkynes, Dienes, and Orbital Symmetry. Aromaticity and Benzene. Aromatic Substitution, Arenes. Spectroscopy and Structure Proof. Alcohols and Thiols. Ethers, Epoxides, Glycols, and Thioethers. Aldehydes and Ketones. Carboxylic Acids. Acid Derivatives. Carbanion-Enolates and Enols. Amines. Phenols and Their Derivatives. Aromatic Heterocyclic Compounds. Amino Acids, Peptides, and Proteins. Carbohydrates.

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Organic Chemistry

Organic Chemistry.

Publisher: Thomson Brooks/Cole | ISBN: 0534373666 | edition 1999 | DJVU | 1338 pages | 13,57 mb

Widely and consistently praised as the most clearly written book on the market. Why? In John McMurry's words: "I have been asked hundreds of times over the past ten years why I wrote this book. I wrote this book because I love writing. I get great pleasure and satisfaction from taking a complicated subject, turning it around until I see it clearly from a new angle, and then explaining it in simple words. I write to explain chemistry to students the way I wish it had been explained to me years ago." Through his lucid writing and ability to show the beauty and logic of organic chemistry, McMurry makes learning enjoyable for students. The highest compliment that can be given to a chemistry book applies to McMurry: It works! Mainstream in level, McMurry's coverage is concise yet doesn't omit any key topics. McMurry blends the traditional functional-group approach with a mechanistic approach. The primary approach, by functional group, begins with the simple and progresses to the more complex so that readers who are not yet versed in the subtleties of mechanisms are first exposed to the what of chemistry before beginning to grapple with the why. Within this primary organization, the author places a heavy emphasis on explaining the fundamental mechanistic similarities. Currently in use at hundreds of colleges and universities throughout the United States and Canada, McMurry's Organic Chemistry is also an international bestseller from the United Kingdom to the Pacific Rim.

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Organic Synthesis: State of the Art 2003 - 2005

Organic Synthesis: State of the Art 2003 - 2005.

Publisher: Wiley-Interscience | ISBN: 0470053313 | edition 2006 | PDF | 216 pages | 10,7 mb

The first in a new series, this book provides chemists an effective, much-needed way to stay abreast of recent developments in organic synthesis. The 103 articles review the leading synthetic procedures developed from 2003 - 2005, discussing their significance and their applications. More than 100 reactions are covered, including Heterocycle Construction by Grubbs Metathesis, Enantioselective C-C Bond Construction, and Organic Reactions in Ionic Liquids.

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The End of Stress As We Know It By Bruce McEwen, Elizabeth Norton Lasley, Elizabeth Lasley

The End of Stress As We Know It By Bruce McEwen, Elizabeth Norton Lasley, Elizabeth Lasley.

Publisher: National Academies Press 2002-10-15 | 285 Pages | ISBN: 0309077201 | PDF | 4.56 MB

There’s a whole new way to think about stress. Sure, some stress is inevitable, but being “stressed out” isn’t. In fact, we can learn to rechannel the powerful stress activators in our lives to make us even more effective.

Hamlet spoke of “suffering the slings and arrows of outrageous fortune.” These days we simply use the word “stress” to describe that feeling. And if you ask 10 random people if they feel stressed, chances are that at least 9 will reply with a resounding, “Yes!” Indeed, the very way we use the word implies that we are its victims—as in, “I’m under so much stress” or “I’m completely stressed out.” There’s now a better way to look at this picture, a way to move from victim to victor. The first step is to look to the science behind it all because in the science lies a whole new message about stress. Science allows us to understand what the stress response is and why our bodies react the way they do. Like all living creatures, we’re mapped to respond instinctually in certain ways, and generally for good reasons. We know, for example, that in times of emergency, we effortlessly shift into a different biological mode. Based on our perception of the crisis, our brains initiate the “stress response” or the “flight-or-fight reaction.” Our attention becomes keenly focused. Our heart and lungs accelerate to ready us for action. Our glands mobilize extra energy resources and summon the immune system to battle stations. This whole process is Nature’s way of empowering us to respond swiftly, sometimes dramatically, to sudden events, while remaining mentally alert and physically prepared to meet a challenge.

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Information Retrieval - SciFinder

Information Retrieval - SciFinder.

By Damon Ridley

Publisher: Wiley

• Number Of Pages: 232
• Publication Date: 2009-12-21
• ISBN-10 / ASIN: 0470712473
• ISBN-13 / EAN: 9780470712474

Product Description:

SciFinder is rapidly becoming a preferred means to access scientific information in industry and universities worldwide. It accesses databases which span the chemical, engineering, life, medical, and physical sciences, including five Chemical Abstract Service databases and the National Library of Medicine bibliographic database Medline. No other single information access tool has such breadth of coverage for scientific journal and patent documents.

Information Retrieval: SciFinder, 2^nd Edition is an essential guide explaining how to get the best out of SciFinder. It discusses the 50+ options in SciFinder including topic, bibliographic, and chemical substance explore options, and post-processing options Analyze, Refine, and Categorize. The book:

• Summarises the databases and explains how to take advantage of the unique search and analysis options
• Explains selected algorithms behind the operation of SciFinder and why it helps to understand them
• Discusses why it is important, and how to apply scientific method to information retrieval
• Describes how to search for chemical structures and chemical reactions

This second edition of Information Retrieval: SciFinder has been fully revised and updated to incorporate the latest functionality and content of SciFinder. Written by a scientist for scientists, this book will increase your research creativity and productivity and is an essential resource for anyone needing scientific information in academia or industry.

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Wiley Guide to Chemical Incompatibilities, 3rd Edition

Wiley Guide to Chemical Incompatibilities, 3rd Edition.

By Richard P. Pohanish, Stanley A. Greene

• Publisher: Wiley
• Number Of Pages: 1110
• Publication Date: 2009-08-17
• ISBN-10 / ASIN: 0470387637
• ISBN-13 / EAN: 9780470387634

Product Description:

"This book should be a required reference on the laboratory's safety shelf as no where else is so much useful information available in a single volume."

Inside Laboratory Management, on the Second Edition

"...a portable reference on reactive substances to guide all personnel...in charge of the handling, storage, and transportation of chemical materials."

Journal of the American Chemical Society, on the Second Edition

The authoritative resource on dangerous chemical interactions now enlarged, revised, and even more useful.

The term "incompatibilities" describes a wide range of chemical reactions that produce undesirable results in noncontrolled situations: the generation of toxic gases, fire, explosions, corrosive activity, polymerization, ruptured containers, creation of more dangerous compounds, and the like. A portable and easy-to-use reference on reactive substances commonly found in commerce, the Wiley Guide to Chemical Incompatibilities, Third Edition compiles hard-to-find data on over 11,000 chemical compounds, providing chemists, technicians, and engineers a thorough, lightning-quick resource to use during experimental preparation and in the event of an emergency.

More than a revision of the previous edition, this Third Edition has been rewritten and expanded to broaden coverage and improve its usefulness. It contains nearly 9,000 chemical incompatibility profiles and nearly 250 new entries, covering flammability, violent and explosive binary reactions, incompatibilities, and reactions that may result from physical change. Alphabetical organization provides concise incompatibility profiles for thousands of commonly used commercial chemicals, allowing readers to look up a given substance and instantly learn whether it is incompatible with common materials, other chemical substances, structural materials, or personal protective equipment.

New for the Third Edition:

• Chemicals that have the potential to cause disasters
• Chemical formulas and autoignition temperatures
• More flash points, as well as molecular formulas, lower and upper explosive limits, autoignition temperatures, and NFPA®-type (Red) numerical fire codes
• Safety reminders
• All entries keyed by CAS numbers to eliminate possible confusion among synonyms
• Spanish-, French-, and German-language entries for international use
• Revised glossary helps users who may not be chemists with general chemical terms

With thousands of new entries and easy-to-use organization, the Third Edition of the Wiley Guide to Chemical Incompatibilities remains a handy resource for all safety, first-response, and plant management professionals responsible for the handling, storage, and conveyance of chemical materia.

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http://www.filefactory.com/file/a09bdd7/n/0470387637_Incompatibilities313_rar