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Thursday, March 25, 2010

Pharmaceutical Bioassays: Methods and Applications

Pharmaceutical Bioassays: Methods and Applications.
By Shiqi Peng, Ming Zhao

Publisher: Wiley
Number Of Pages: 497
Publication Date: 2009-11-09
ISBN-10 / ASIN: 0470227605
ISBN-13 / EAN: 9780470227602

Product Description:

The definitive compendium of bioassay procedures and applications

A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of pharmacological models.

Demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules, the book covers the evaluation and screening of drug compounds in a wide spectrum of therapeutic categories.

Throughout, the authors use various models to link experimental observations with findings that clarify the effect of drug compounds on cellular biology and measure the pharmacological activity of chemical substances. This provides an important technological platform for successful drug research and clinical therapy, making Pharmaceutical Bioassays an ideal sourcebook for pharmacologists, pharmaceutical and medical researchers, analytical chemists, toxicologists, and students.

Just as a fundamental knowledge of pharmaceutical bioassays is vital to understanding how bioactive agents and new drugs are defined, discovered, and developed, so too is this indispensable reference, which:

Offers a complete reference on pharmaceutical bioassays and their specific applications in the assessment of therapies for cancer, Alzheimer's, diabetes, epilepsy, inflammation, antimalarials, pharmacogenomics, and other major therapeutic areas

Covers bioassays that measure toxicity, including those for chemical toxicity and hepatoxicity—a particularly significant consideration in the development of safe and tolerable medications
Highlights clinically relevant methods, ideas, and techniques to support any pharmaceutical researcher

Suggests guidelines and systems to enhance communication between pharmacologists, chemists, and biologists

Provides an informative analysis of pharmaceutical bioassay technologies and lab applications.


Reactive Intermediates: MS Investigations in Solution

Reactive Intermediates: MS Investigations in Solution.
By Leonardo S. Santos

  • Publisher: Wiley-VCH
  • Number Of Pages: 341
  • Publication : 2010-02-22
  • ISBN-10 / ASIN: 3527323511
  • ISBN-13 / EAN: 9783527323517

Product Description:

Edited by a top expert, this book represents a powerful tool showing how to successfully apply ESI-MS in revealing, elucidating and helping to consolidate several proposed mechanisms of reactions that need to be emphasized.
With a foreword by Chris Enke


Mass spectrometry could be described, without implying any criticism, as an
example in progress. Each time it appears to be approaching maturity,
another breakthrough occurs to expand its usefulness in new areas of science. As
this volume clearly demonstrates, that process is still going on. In the early twentieth
century, mass spectrometry was principally a tool for physicists to study particles
and petroleum chemists to characterize petroleum mixtures.Wider use by chemists
began with the ability to obtain structural information from the spectra of pure
organic molecules. The analytical application of mass spectrometry truly came of age
with its use as a detector for gas chromatography. Indeed, up to the present, advances
in chromatography and mass spectrometry have leapfrogged each other, combining
to create analytical tools that have steadily advanced in selectivity and detection limit
for over two decades. The power of these tools is such that they have found critical
applications in virtually every area of science,medicine.
From the standpoint of mass spectrometric instrumentation, the story of this
evolution has taken place on four fronts:

(1) Methods of separating ions of different atomic or molecular masses
(2) Methods of obtaining more chemical information by tandem mass spectrometry
(3) Methods of ionizing analyte molecules
(4) Methods that improve sensitivity and throughput.

Spectacular advances in all four of these areas have facilitated the remarkable
expansion of mass spectrometry in diverse areas, including the subject of this
volume. Sometimes new applications are introduced by mass spectrometrists
recognizing an area of opportunity and sometimes by researchers in that area
who have the temerity and opportunity to try a new technique. In any case,
mass spectrometry has become a central tool in scientific investigation, and
facilities for its use have become a critical part of virtually all scientific research

Most analytical methods use a bulk property to distinguish, separate, or identify an
analyte. Properties such as chemical reactivity, chromatographic retention time, and
optical absorbance or emission reveal information about an aggregate of analyte
molecules, giving a collective response value. A remarkable thing about a mass
spectrum, and one of the unique attributes of mass spectrometry, is that the analyte
molecules or atoms are separated by mass, and the detector records the mass of each
individual analyte molecule. The isotopic composition of the analyte is revealed as
are mass shifts due to modifications of very large molecules, even when only a
fraction of them have been modified.
To perform a separation of sample molecules or atoms according to their individual
masses, all mass spectrometers rely on the fact that the trajectory of a charged
particle in the presence of electric and magnetic fields is mass-dependent, or, more
exactly, dependent on the mass-to-charge ratio (m/z) of the particle. To avoid
distortion of the differentiating trajectory by collisions with molecules, this separation
must be carried out in a vacuum, though, as we shall see, sometimes such
collisions can be used to advantage.
Chapter 1 in this volume reviews the historical development of mass spectrometers
in some detail. I will here introduce the general concepts of mass separation
in the context of some seminal developments in the instrumentation. Ions
accelerated to a nearly constant kinetic energy (1/2 mv2) will, in a region with
uniform magnetic field, have a curved trajectory dependent on the ion momentum.
Magnetic sector mass spectrometers, based on this principle, held a dominant
position for many years. The addition of an electric sector greatly improved
the mass resolution, and these double-focusing mass spectrometers were the
gold standard into the 1990s. Obtaining mass resolutions in the tens of thousands
enabled the development of exact mass determination, whereby the amount of
the mass defect in the elements could be used to determine the chemical formula
of an analyte based on the measurement of the ion m/z to within some few parts
per million. The champion, however, for mass resolution has been the Fourier
transform ion cyclotron resonance (FTICR) mass spectrometer introduced by
Marshall and Comisarow in 1974. Ions in a very high magnetic field move in a
circle on a plane orthogonal to the magnetic field flux. The frequency of their
rotation is a function of their m/z value. A batch of ions is excited to rotation and
the resulting signal is analyzed by Fourier Transform to obtain the frequencies
and thus the m/zs of the ions in the batch. Mass accuracies in small fractions of
parts per million have been achieved.
Though mass analysis based on ion flight time was an early innovation, the lack
of good high-speed electronics and its poor mass resolution prevented its wide
adoption. What did bring mass spectrometry into the main stream of chemical
analysis was the development of the quadrupole mass spectrometer. This simple
device provided unit resolution mass spectra in a relatively compact, low-cost
format. The quadrupole mass analyzer with gas chromatography
resulted in a powerful analytical tool that continues to see wide use in a variety.


Sunday, March 21, 2010

Handbook of Analytical Techniques (2 Volume Set)

Helmut Günzler, Alex Williams, "Handbook of Analytical Techniques (2 Volume Set)" .
Wiley-VCH | 2001 | ISBN: 3527301658 | 1198 pages | PDF | 40,5 MB

The "Handbook of Analytical Techniques" serves as a concise, one-stop reference source for every professional, researcher, or student using analytical techniques. All relevant spectroscopic, chromatographic, and electrochemical techniques are described, including chemical and biochemical sensors, as well as e. g. thermal analysis, bioanalytical, nuclear or radiochemical techniques. Special articles are devoted to general topics such as chemometrics, sampling, and sample preparation.
All articles were written and reviewed by acknowledged experts. They cover the fundamentals, instrumentation, and applications of each technique. Numerous references for each article facilitate access to the primary literature.
This two-volume handbook comprises almost 1,200 pages with more than 900 figures and has an attractive two-column page layout. It is the key source for problemsolving in all areas of analysis, e. g. of food, water, wastewater, air, soil, biomolecules, pharmaceuticals, or for materials characterization.


Introduction to Coordination Chemistry

Geoffrey Alan Lawrance, "Introduction to Coordination Chemistry" .
Wiley | 2010 | ISBN: 0470519312, 0470519304, 0470687134 | 304 pages | PDF | 4,8 MB

Introduction to Coordination examines and explains how metals and molecules that bind as ligands interact, and the consequences of this assembly process. This book describes the chemical and physical properties and behavior of the complex assemblies that form, and applications that may arise as a result of these properties. Coordination complexes are an important but often hidden part of our world?even part of us?and what they do is probed in this book. This book distills the essence of this topic for undergraduate students and for research scientists.


Stockley's Drug Interactions Pocket Companion 2010

Karen Baxter, "Stockley's Drug Interactions Pocket Companion 2010".
Pharmaceutical Press | 2010 | ISBN: 0853699178 | 495 pages | PDF | 2,2 MB

Extensively updated to reflect the latest findings and provides busy healthcare professionals with a small and conveniently sized, quick-referenceStockleytext.It draws on the wealth of clinically evaluated, evidence-based information on drug-drug, drug-herb and drug-food interactions that is presented in the full reference work,Stockley's Drug Interactions.• Follows the familiar format of theStockleyproducts• Includes nearly 1550 interaction monographs pertaining to specific drugs or drug groups• Arranged alphabetically for ease of searching• Contains a comprehensive index• Easy-to-use severity rating symbols offer guidance to the user on the clinical significance of the interaction• An essential clinical reference for physicians, pharmacists, nurses and other healthcare professionals.Due to the wide international appeal of this content, the text is now translated into Spanish, Italian and Japanese.


Product Research: The Art and Science Behind Successful Product Launches

N. R. Srinivasa Raghavan, John A. Cafeo, "Product Research: The Art and Science Behind Successful Product Launches"
Springer | 2009 | ISBN: 9048128595 | 305 pages | PDF | 2,9 MB

This book is a collection of research papers to be presented at the GM R&D India Science Lab workshop on Art and Science of Product Development held at Bangalore, India. Leading researchers from around the world, and from within GM, present some of their latest research and experience around methodologies and analytics that we believe, are very critical to any product development activity. This book has articles in four major pillars of product development research: a, uncertainty modeling and information integration; b, role of behavioral research in understanding customer requirements and designing products; c, advanced analytical approaches for identifying voice of the customer; and d, human centered decision making and its role in product development.


Biotechnology and the Patent System: Balancing Innovation and Property Rights

Claude Barfield, "Biotechnology and the Patent System: Balancing Innovation and Property Rights" .
AEI Press | 2007 | ISBN: 0844742562 | 132 pages | PDF | 1 MB

Evaluates proposals for for overall patent reform thorugh administrative and legislative routes, with the goal of achieving an efficient and equitable balance between the rights of patent-holders and those of challengers.


Symmetrical Analysis Techniques for Genetic Systems and Bioinformatics: Advanced Patterns and Applications

Sergey Petoukhov, Matthew He, "Symmetrical Analysis Techniques for Genetic Systems and Bioinformatics: Advanced Patterns and Applications".
Medical Information Science Reference | 2009 | ISBN: 1605661244 | 271 pages | PDF | 10,1 MB

Mathematical and symmetrical analysis of the structure of molecular systems of genetic code has essential meaning for the bioinformatics, biomathematics, and biotechnology fields. Symmetrical Analysis Techniques for Genetic Systems and Bioinformatics: Advanced Patterns and Applications adds unique and novel value to the literature in these areas, compiling studies that demonstrate effective approaches to the structural analysis of genetic systems and bioinformatics. This groundbreaking reference advances the knowledge available to researchers, educators, and students about new mathematical methods and tools, phenomenological results and interdisciplinary connections in the fields of molecular genetics, bioinformatics, computer informatics, and mathematical and theoretical biology.


Molecular Orbitals and Organic Chemical Reactions

Ian Fleming, "Molecular Orbitals and Organic Chemical Reactions" .
Wiley | 2010 | ISBN: 0470746599 | 376 pages | PDF | 10,8 MB

Molecular orbital theory is used by chemists to describe the arrangement of electrons in chemical structures. It is also a theory capable of giving some insight into the forces involved in the making and breaking of chemical bonds—the chemical reactions that are often the focus of an organic chemist’s interest. Organic chemists with a serious interest in understanding and explaining their work usually ex their ideas in molecular orbital terms, so much so that it is now an essential component of every organic chemist’s skills to have some acquaintance with molecular orbital theory.

Molecular Orbitals and Organic Chemical Reactions is both a simplified account of molecular orbital theory and a review of its applications in organic ; it pres a basic introduction to the subject and a wealth of illustrative examples. In this book molecular orbital theory is presented in a much simplified, and entirely non-mathematical language, accessible to every organic chemist, whether student or research worker, whether mathematically competent or not. Topics covered include:
Molecular Orbital Theory
Molecular Orbitals and the Structures of Organic Molecules
Chemical Reactions — How Far and How Fast
Ionic Reactions — Reactivity
Ionic Reactions — Stereo
Pericyclic Reactions
Radical Reactions
Photochemical Reactions

Molecular Orbitals and Organic Chemical Reactions: Student Edition is an invaluable first textbook on this important subject for students of organic, physical organic and computational .


A Practical Guide to Scientific Data Analysis

David J. Livingstone, "A Practical Guide to Scientific Data Analysis"
Wiley | 2010 | ISBN: 0470851538 | 358 pages | PDF | 2,8 MB

Inspired by the author's need for practical guidance in the processes of data analysis, A Practical Guide to Scientific Data Analysis has been written as a statistical companion for the working scientist. This handbook of data analysis with worked examples focuses on the application of mathematical and statistical techniques and the interpretation of their results.

Covering the most common statistical methods for examining and exploring relationships in data, the text includes extensive examples from a variety of scientific disciplines.

The chapters are organised logically, from planning an experiment, through examining and displaying the data, to constructing quantitative models. Each chapter is intended to stand alone so that casual users can refer to the section that is most appropriate to their problem.

Written by a highly qualified and internationally respected author this text:
Presents statistics for the non-statistician
Explains a variety of methods to extract information from data
Describes the application of statistical methods to the design of “performance chemicals”
Emphasises the application of statistical techniques and the interpretation of their results

Of practical use to chemists, biochemists, pharmacists, biologists and researchers from many other scientific disciplines in both industry and academia.


Wednesday, March 17, 2010

Esterification: Methods, Reactions, and Applications

Esterification: Methods, Reactions, and Applications.
By Junzo Otera, Joji Nishikido

  • Publisher: Wiley-VCH
  • Number Of Pages: 386
  • Publication Date: 2010-02-02
  • ISBN-10 / ASIN: 3527322892
  • ISBN-13 / EAN: 9783527322893

Product Description:

Gathering together the widespread literature in the field, this monograph acts as a reference guide to this very important chemical reaction. Following an introduction, thegoes on to discuss methodology, before treating synthetic and industrial applications -- the latter being a new focus in this completely revised, updated and extended second edition.
A must-have for organic, and catalytic chemists, as well as those working in industry, of for lecturers in chemistry.



Advances in Fischer-Tropsch Synthesis, Catalysts, and Catalysis

Advances in Fischer-Tropsch Synthesis, Catalysts, and Catalysis.
By B. H. Davis, Mario L. Occelli

  • Publisher: CRC Press
  • Number Of Pages: 424
  • Publication Date: 2009-11-10
  • ISBN-10 / ASIN: 1420062565
  • ISBN-13 / EAN: 9781420062564

Product Description:

Rising oil costs have stimulated significant interest in the Fischer-Tropsch synthesis (FTS) as a method for producing a synthetic petroleum substitute. Drawn from the proceedings at a symposium held during the 236th meeting of the American Society in Philadelphia in August 2008, Advances in Fischer-Tropsch Synthesis, Catalysts, and Catalysis explores the recent developments in Fischer-Tropsch technology, which holds great promise in the area of renewable resources.

Expert contributors explore a range of issues

The focuses on three main themes: catalyst preparation and activation, reaction mechanism, and process-related topics. A panel of expert contributors discusses synthesis of catalysts, nanomaterials, nitric oxide calcinations, the influence of carbon, catalytic performance issues, chelating agents, and Cu and alkali promoters. They also explore Co/silica catalysts, thermodynamic control, the Two Alpha model, co-feeding experiments, internal diffusion limitations, Fe-LTFT selectivity, and the effect of co-fed . Lastly, the book examines cross-flow filtration, kinetic studies, reduction of CO2 emissions, syncrude, and low-temperature water-gas shift.

Attaining the maximum catalytic activity and catalyst life

The themes explored in the book demonstrate that while the Fischer-Tropsch synthesis (FTS) has advanced in maturity, many issues remain concerning the preparation of increasingly active catalysts and the method of activation to attain the maximum catalytic activity and catalyst life. The book includes coverage of the structural features, their changes, and the application of increasingly sophisticated characterization techniques, shedding light on the reaction mechanism and providing a glimpse into the processes and reaction rates under realistic commercial process conditions.



Teacher's Handbook of Chemistry

Publication: Chandni Chowk, Delhi Global Media, 2009.

Subject: Chemistry--Handbook

Pages: 250

eBook ISBN: 9789380168937


1. Place of Chemistry in Science
2. Programmed Teaching
3. The Background
4. Role of the Teacher
5. Methods of Teaching
6. Aims and Objects of Teaching
7. Teaching Aids
8. Role



Chromatography of Aroma Compounds and Fragrances

Chromatography of Aroma Compounds and Fragrances.
By Tibor Cserháti

  • Publisher: Springer
  • Number Of Pages: 392
  • Publication Date: 2010-03-29
  • ISBN-10 / ASIN: 3642016553
  • ISBN-13 / EAN: 9783642016554

Product Description:

This is the only comprehensive survey of chromatographic methods for the analysis of aroma compounds and fragrances. A unique feature of the are the extensive tables with relevant data. This will help significantly to choose an appropriate method, and to compare its characteristics with that of other methods. Coverage of applications includes essential oils, as well as environmental samples. Tibor Cserháti is a recognized member of the separation science community with long-standing experience. He is author or coauthor of six books and more than 490 scientific papers.


Asymmetric Organocatalysis

Asymmetric Organocatalysis (Topics in Current Chemistry, Volume 291)
By Benjamin List
  • Springer
  • Number Of Pages: 400
  • Publication Date: 2010-03-28
  • ISBN-10 / ASIN: 3642028144
  • ISBN-13 / EAN: 9783642028144
Product Description:
The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern research. The scope of coverage includes all areas of science including the interfaces with related disciplines such as biology, medicine and materials science.

The goal of each thematic volume is to give the non-specialist reader, whether at the university or in industry, a comprehensive overview of an area where new insights are emerging that are of interest to a larger scientific audience.

Thus each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years should be presented using selected examples to illustrate the principles discussed. A description of the procedures involved is often useful to the reader. The coverage should not be exhaustive in data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Discussion of possible future directions in the area is welcome. Review articles for the individual volumes are invited by the volume editors.

Chapters in this volume:
* Noncovalent Organocatalysis Based on Hydrogen Bonding: Elucidation of Reaction Paths by Computational Methods
* Enamine Catalysis
* Carbene Catalysts
* Brønsted Base Catalysts
* Chiral Ketone and Iminium Catalysts for Olefin Epoxidation
* Amine, Alcohol and Phosphine Catalysts for Acyl Transfer Reactions
* Secondary and Primary Amine Catalysts for Iminium Catalysis
* Lewis Acid Organocatalysts
* Chiral Brønsted Acids for Asymmetric Organocatalysis.


Pharmaceutical Packaging Handbook

 by: Edward Bauer

Pharmaceutical Packaging Handbook
By EdwardBauer

· Publisher: Informa Healthcare

· Number Of Pages: 350

· Publication Date: 2009-03-24

· ISBN-10 / ASIN: 1587161516

· ISBN-13 / EAN: 9781587161513

Product Description:

A complete overview of the role that packaging plays in the development and delivery of pharmaceuticals and medical devices. Including a thorough examination of the industry in size and scope, this source gives an introduction drug dosage forms, vaccines, biologically produced products, and medical foods to the reader.

Pharmaceutical Packaging Handbook is the most complete and straightforward text on the market today and also lists information in an easy to follow fashion, making it a complete stand-alone reference for anyone working in the pharmaceutical industry.

Pharmaceutical Packaging Handbook:

discusses how packaging is designed and integrated into the product development cycle has an overview of the regulatory environment procedures provides the reader with a basic introduction into key aspects of navigating the regulations describing the materials used to package pharmaceuticals, including glass, metal, plastics, flexible films, rubbers and elastomers comments on some new hybrids used for packaging, with a short introduction to plastics, their makeup, and typical uses in packaging explores the processing techniques used with the materials to produce pharmaceutical containers and some of the strengths and weaknesses of the processes used for container fabrication introduces the reader to retort, aseptic, gas, and radiation sterilization of product discusses labeling and design for pharmaceuticals including how labels are produced, materials used, and production techniques



Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications, 4th Edition

Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications, 4th Edition.
By Jie Jack Li

  • Number Of Pages: 621
  • Publication Date: 2009-09-10
  • ISBN-10 / ASIN: 3642010520
  • ISBN-13 / EAN: 9783642010521

Product Description:

The fourth edition is revolutionary in comparison to the previous three editions. The format change has doubled the space to accommodate at least two to three real case applications in synthesis for each name reaction. The references are updated to 2009. Several new name reactions and reagents are included to reflect the state-of-the-art of organic chemistry.

Unlike other on name reactions in organic chemistry, Name Reactions, A Collection of Detailed Reaction Mechanisms and Synthetic Applications focuses on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. Now with addition of many synthetic applications, it is not only an indispensable resource for senior undergraduate and graduate students for learning and exams, but also a good reference book for all organic chemists interested in name reactions.