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Monday, January 31, 2011

Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry

Peter Dunn, Andrew Wells, Michael T. Williams, "".
Wiley-VCH | 2010 | ISBN: 3527324186 | 388 pages | PDF | 5,8 MB

Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.



Assay Development: Fundamentals and Practices

Assay Development: Fundamentals and Practices

Ge Wu, "Assay Development: Fundamentals and Practices".
Wiley | 2010 | ISBN: 0470191155, 0470583118 | 429 pages | PDF | 5,2 MB

Essential principles and practice of assay development

The first comprehensive, integrated treatment of the subject, Assay Development: Fundamentals and Practices covers the essentials and techniques involved in carrying out an assay project in either a biotechnology/drug discovery setting or a platform setting.

Rather than attempting comprehensive coverage of all assay development technologies, the book introduces the most widely used assay development technologies and illustrates the art of assay development through a few commonly encountered biological targets in assay development (e.g., proteases, kinases, ion channels, and G protein-coupled receptors). Just enough biological background for these biological targets is provided so that the reader can follow the logics of assay development. Chapters discuss:

•The basics of assay development, including foundational concepts and applications

•Commonly used instrumental methods for both biochemical assays and cell-based assays

•Assay strategies for protein binding and enzymatic activity

•Cell-based assays

•High-throughput screening

An in-depth study of the now popular Caliper's off-chip kinase assay provides an instructive, real-world example of the assay development process.



Modern Drug Synthesis

Modern Drug Synthesis

Jie Jack Li , Douglas S. Johnson, "Modern Drug Synthesis".
Wiley | 2010 | ISBN: 0470525835 | 355 pages | PDF | 5,4 MB

The all-inclusive book on the cutting-edge science driving the medicinal chemistry of the latest drugs

The successor to the editors' two highly acclaimed works on drug synthesis, Contemporary Drug Synthesis and The Art of Drug Synthesis, this book provides refocused and extensive new coverage detailing how chemistry, biology, and pharmacokinetics integrate to spearhead successful medical findings. Modern Drug Synthesis carries on the mission of delivering the most up-to-date developments unfolding in this rapidly evolving field by placing a stronger emphasis on medicinal chemistry and pharmacology, in addition to drug synthesis. Other highlights include:

Chapters are logically divided into categories such as background of disease area, pharmacology, SAR (structure-activity relationships), pharmacokinetics and drug metabolism, efficacy and safety, and synthesis

Expert analysis of the pros and cons of different synthetic routes

A step-by-step breakdown of today's drug discovery process for professionals and students

Supporting case studies in each chapter

Modern Drug Synthesis shows that whether drug synthesis is in early development or the process stage, the ability to design elegant and economical synthetic routes is often a major factor making a drug a commercial winner. Easy to follow and stacked with valuable information on the present and future direction of medicinal chemistry, Modern Drug Synthesis is the one guide that paints a clear and complete picture of this complex subject.



Wednesday, January 26, 2011

Successful Trouble Shooting for Process Engineers: A Complete Course in Case Studies

Chemical production processes consist of many complex apparatuses involving both moving and static parts as well as interconnecting pipes, control mechanisms and electronics, mechanical and thermal stages, heat exchangers, waste and side product processing units, power ducts and many others. Bringing such a complicated unit online and ensuring its continued productivity requires substantial skill at anticipating, detecting and solving acute problems. This book is the professional's and student's entrance to the fascinating and important world of trouble shooting for chemical, pharmaceutical and other production processes.


Name Reactions for Carbocyclic Ring Formations (Comprehensive Name Reactions)

Product Description: This book continues the well-established and authoritative series on name reactions in organic chemistry by focusing on name reactions on ring formation. Ring formating reactions have found widespread applicability in traditional organic synthesis, medicinal/pharmaceuticals, agricultural, fine chemicals, and of late, especially in polymer science.


The Art of Process Chemistry free download

Author(s): Nobuyoshi Yasuda
Publisher: Wiley-VCH
Date: 2010-12-14
Pages: 298

Product Description: Providing must-have knowledge for the pharmaceutical industry and process chemists in industry, this ready reference offers solutions for saving time and money and supplying -- in a sustainable way -- valuable products. Application-oriented and well structured, each chapter presents successful strategies for the latest modern drugs, showing how to provide very fast bulk quantities of drug candidates. Throughout, the text illustrates how all the key factors are interwoven and dependent on one another in creating optimized methods for optimal products.



Basic Elements of Crystallography.

Teresa Szwacka, Nevill Gonzalez Szwacki, "Basic Elements of Crystallography."
Pan Stanford Publishing | 2010 | ISBN: 9814241598 | 250 pages | File type: PDF | 15,8 mb

A comprehensive introduction to the field of crystallography, this volume includes extensive discussions on various topics, including the 14 Bravais lattices and their reciprocals, the basic concepts of point group symmetry, and the crystal structure of elements and binary compounds. Accompanied by exercises designed to further exploration of crystal structures, these chapters clearly illustrate how atoms are arranged. With high-quality illustrations, this reference is indispensible to students and researchers alike.

This book is intended to be a complete and clear introduction to the field of crystallography. It includes an extensive discussion of the 14 Bravais lattices and the reciprocal to them, basic concepts of point group symmetry, the crystalstructure of elements and binary compounds, and much more. The purpose of this textbook is to illustrate rather than describe ¡°using many words¡± thestructure of materials. Readers who are not at all familiar with the topic but who want to learn how atoms are arranged in crystal structures, will find this book useful. The chapters are accompanied byexercises designed to encourage students to explore the crystal structures he/she is learning about. The entire notation in this book is consistent with the International Tables for Crystallography

Readership: Undergraduate and graduate students and lecturers in physics, chemistry, biology, electrical electronic engineering, and materials science engineering; researchers in physics, chemistry, and nanotechnology.
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Saturday, January 22, 2011

Software Quality Assurance SOPs for Healthcare Manufacturers

Software Quality Assurance SOPs for Healthcare Manufacturers
Publisher: Informa HealthCare | 2002 | ISBN: 157491135X | PDF | 650 pages | 1.8 MB
This work provides not only guidance for generating documents but also templates that can be used to establish the documentation for a software quality assurance program for healthcare manufacturers. Readers can use the policies and guidelines as presented, modify them for use within their organizations, or use them to compare and contrast with any existing software engineering policies and SOPs within their organizations. They can also use the project documentation examples as presented within this volume. In this second edition, all templates have been revised and several new templates have been included.

Multi-Plant Safety and Security Management in the Chemical and Process Industries Book

Multi Plant Safety and Security Management in the Chemical a
Wiley-VCH | 2010 | ISBN: 3527325514 | 290 pages | PDF | 3,3 MB
This practical text serves as a guide to elaborating and determining the principles, assumptions, strengths, limitations and areas of application for multiple-plant chemical safety and security management. It offers guidelines, procedures, frameworks and technology for actually setting up a safety and security culture in a cluster of chemical companies, thus allowing forward planning. The presentation is conceptually rather than mathematically oriented so as to maximize its utilization within the chemical industry.

Quality Assurance A Guide to the Application of Iso 9001 to

Quality Assurance A Guide to the Application of Iso 9001 to
Publisher: Gulf Publishing Company; 2 Sub edition (July 1, 1996) | ISBN-10: 0852953720 | ISBN-13: 978-0852953723 | 64 Pages | PDF | 1.4 MB
Guide to the application of ISO 9001 to process plant projects. Fully revised and expanded to take into account the revision of ISO 9001 in 1994. Paper.
IChemE, the Institution of Chemical Engineers, is the center for chemical, biochemical and process engineering professionals worldwide.
We are the heart of the process community, promoting competence and a commitment to sustainable development, advancing the discipline for the benefit of society and supporting the professional development of members.
Some of the areas we publish in include:
-Safety in the process industries - the BP Process Safety series
-Consultancy for chemical engineers
-Project management in the process industries
-Contract management in the process industries - International Forms Of Contract series.

Engineers Guide to Rotating Equipment The Pocket Reference

Engineers Guide to Rotating Equipment The Pocket Reference
Wiley | 2001 | ISBN: 186058344X | 352 pages | PDF | 3,4 MB
This handy reference source is a companion volume to the author's Engineers' Guide to Pressure Equipment. Heavily illustrated, and containing a wealth of useful data, it offers inspectors, engineers, operatives, and those maintaining engineering equipment a one-stop, everyday package of information. It will be particularly helpful in guiding users through the European Machinery Directive regulating this field. It also incorporates both technical and administrative aspects of rotating equipment manufacture and use, introducing the basic principles of balancing, vibration, noise, and inspection/testing of a wide range of equipment. It makes references to the most commonly used current and recent technical codes and standards, and simplifies their complex content into a form that is easier to understand. Key features: Essential engineering data from a wide range of sources, Practical and easy-to-use format, Compact and easily accessible, Fully illustrated, and Core technical/legislative data. Engineers' Guide to Rotating Equipment will be a great source of interest and value to engineers, technicians, and students with activities in the rotating equipment business.

Process Plant Machinery 2 Ed

Process Plant Machinery 2 Ed
Butterworth-Heinemann | 1998 | ISBN: 0471396435 | 734 pages | PDF | 55 MB
Process Plant Machinery provides the mechanical, chemical or plant engineer with the information needed to choose equipment best suited for a particular process, to determine optimum efficiency, and to conduct basic troubleshooting and maintenance procedures.
Process Plant Machinery is a unique single-source reference for engineers, managers and technical personnel who need to acquire an understanding of the machinery used in modern process plants: prime movers and power transmission machines; pumping equipment; gas compression machinery; and mixing, conveying, and separation equipment. Starting with an overview of each class, the book quickly leads the reader through practical applications and size considerations into profusely illustrated component descriptions. Where necessary, standard theory is expertly explained in shortcut formulas and graphs. Maintainability and vulnerability concerns are dealt with as well.
-- Fully updated with all new equipment available
-- Comprehensive Coverage
-- Multi-industry relevanc.


Plant Design and Economics for Chemical Engineers Book

Plant Design and Economics for Chemical Engineers
Publisher: McGraw-Hill Companies | ISBN: 0070496137 | edition 1990 | PDF | 925pages | 14 mb
A revision of the classic text-reference for the chemical engineering "design" course usually offered to all Chemical Engineers at the junior/senior level. This new edition contains the latest cost data as well as new emphasis on safety and H42OPS and a new chapter on Computer-Aided Design. The book nicely balances both economics (cost estimating and cost data) and process equipment design in one text.

Practical Laboratory Skills Training Guide: Gas Chromatography Book.

Practical Laboratory Skills Training Guide Gas Chromatograp
Royal Society of Chemistry; 1 edition | May 12, 2003 | ISBN-10: 0854044787 | 36 pages | PDF | 1.1 Mb
Gas chromatography has been the most widely used technique in analytical chemistry for over three decades. It offers unchallenged resolving power for closely related volatile compiunds and high sensitivity and selectivity with many of the detector systems. This technique is very accurate and precise when used in the laboratory. This guide begins by looking at the basic theory behind gas chromatography, then goes on to examine injection and sampling methods and the chromatographic column. Sections on detection, data handling, calibration and standards are followed by problem-solving and practical exercises. "Gas Chromatography" is one of the "Practical Laboratory Skills Training Guides", a series that aims to make achieving best practice easy. These invaluable manuals will enable both experienced and inexperienced staff to get the essential basics of any experiment right simply by following the clear and easy to use instructions provided. The guides are written by experienced scientists and include minimal theory, plenty of practical exercises in order to assess competence, and trouble shooting information.

The Laboratory Companion A Practical Guide to Materials Equipment.

The Laboratory Companion A Practical Guide to Materials Eq
Publisher: Wiley-Interscience | ISBN: 0471780863 | edition 2005 | PDF | 549 pages | 14,8 mb
The Laboratory Companion, is a valuable reference guide for all those working in scientific laboratories. The range of information provided covers commonly used materials, equipment, and techniques found in most labs. Safety practices and safe procedures are constantly emphasized when discussing the proper methods of selecting, using, cleaning, and maintaining laboratory equipment (vacuum, compressed gases, measurement equipment, cryogenics, and other), as well as a thorough discussion of glassware.




Process Plant Layout and Piping Design Book

Process Plant Layout and Piping Design
Publisher: Prentice Hall | ISBN: 0131386298 | edition 1993 | PDF | 460 pages | 25,4 mb
Based on the authors' collective 65 years of experience in the engineering construction industry, this profusely illustrated, comprehensive guidebook presents tried-and-true workable methods and rules of thumb for plant layout and piping design for the process industries. Content is organized and presented for quick-reference on-the-job or for systematic study of specific topics. Presents general concepts and principles of plant layout -- from basic terminology and input requirements to deliverables; deals with specific pieces of equipment and their most efficient layout in the overall plant design configuration; addresses the plant layout requirements for the most common process unit equipment; covers piping requirements for the entire plant as well as all equipment types; and considers the computerized tools that are now available to help plant layout and piping designers. Features more than 640 illustrations of equipment, piping and other components of processing facility -- and their configurations.

A Working Guide to Process Equipment

A Working Guide to Process Equipment
Publisher: McGraw-Hill | ISBN: 0070380759 | edition 1996 | PDF | 425 pages | 14,4 mb
Chemical engineers and technicians often can't identify the source of equipment malfunctions because they don't understand how the equipment works. This easy-to-read guide offers explanations of the inner workings of equipment in petroleum refineries, chemical and pharmaceutical plants, fertilizer plants, and other continuous process facilities. Tips, worked out calculations, and simple process figures expedite troubleshooting of problems in heaters, turbines, vacuum systems, instrumentation, refrigeration systems, compressors, and much more.




Royal Society of Chemistry | January 2002 | ISBN-10: 085404602X | 170 pages | PDF | 14.79 Mb
Stereochemistry is defined as the study of the three-dimensional structure of molecules. Stereochemical considerations are important in both isomerism and studies of the mechanisms of chemical reactions. Implicit in a mechanism is the stereochemistry of the reaction: in other words, the relative three-dimensional orientation of the reacting particles at any time in the reaction. Concentrating on organic chemistry, early chapters deal mainly with definitions of terms such as chirality, enantiomers, diastereoisomers and racemisation, complete with suitable examples to illustrate key concepts. Use of a polarimeter and associated definitions are described, together with two different conventions D, L and R, S for specification of configuration. Chirality without a stereogenic centre, in molecules such as allenes for example, is also covered. The distinction between conformation and configuration is developed to include assignment of configurations to di-substituted cyclohexanes and to the decalins. The conventions E, Z and Re, Si are introduced for sp2 hybridised carbons as found in alkenes and carbonyl compounds. These aspects of stereochemistry are further explored through consideration of reactions such as SN2, elimination and addition reactions, ester hydrolyses, electrocyclic reactions and Diels-Alder cycloadditions.




Hetero Diels-Alder Methodology in Organic Synthesis Book

Hetero Diels Alder Methodology in Organic Synthesis
Publisher: Academic Press | ISBN: 0121108600 | edition 1987 | PDF | 366 pages | 13,1 mb
In the course of our individual research programs, we have had occasion to utilize hetero Diels-Alder reactions as pivotal steps in natural product total syntheses. It became clear to us during the early stages of our work that this type of cycloaddition, although a potentially powerful synthetic tool, had found relatively little general use. Moreover, it was also evident that reviews on various aspects of this chemistry were often out-of-date or nonexistent. In response to this situation, we have written several journal reviews on different facets of hetero Diels-Alder methodology during the past few years. With an apparent increase in the appreciation of the value of [4 + 21 cycloadditions in heterocyclic synthesis, we felt it was appropriate to write this monograph.

A Comprehensive Guide to the Hazardous Properties of Chemical Substances Book

A Comprehensive Guide to the Hazardous Properties of Chemica
Wiley-Interscience; 3 edition | May 25, 2007 | ISBN-10: 0471714585 | 1059 pages | PDF | 13.4 Mb
The definitive guide to the hazardous properties of chemical compounds. Correlating chemical structure with toxicity to humans and the environment, and the chemical structure of compounds to their hazardous properties, A Comprehensive Guide to the Hazardous Properties of Chemical Substances, Third Edition allows users to assess the toxicity of a substance even when no experimental data exists. Thus, it bridges the gap between hazardous materials and chemistry. Extensively updated and expanded, this reference:
* Examines organics, metals and inorganics, industrial solvents, common gases, particulates, explosives, and radioactive substances, covering everything from toxicity and carcinogenicity to flammability and explosive reactivity to handling and disposal practices
* Arranges hazardous chemical substances according to their chemical structures and functional groups for easy reference
* Includes updated information on the toxic, flammable, and explosive properties of chemical substances
* Covers additional metals in the chapters on toxic and reactive metals
* Updates the threshold exposure limits in the workplace air for a number of substances
* Features the latest information on industrial solvents and toxic and flammable gases
* Includes numerous tables, formulas, and a glossary for quick reference
Because it provides information that enables those with a chemistry background to perform assessments without prior data, this comprehensive reference appeals to chemists, chemical engineers, toxicologists, and forensic scientists, as well as industrial hygienists, occupational physicians, Hazmat professionals, and others in related fields.




Green Reaction Media in Organic Synthesis

Green Reaction Media in Organic Synthesis
Publisher: Wiley-Blackwell | ISBN: 140513402X | edition 2005 | PDF | 200 pages | 1,2 mb
Green, sustainable chemistry involves the designing of chemical processes with a view to reducing or even eliminating the use and production of hazardous materials. Recent endeavors have focused on limiting the use of organic solvents and replacing them with new, environmentally benign media. The chemical industry is interested in these cost-effective, alternative solvents and processes.


Handbook of High performance liquid chromatography, Second Edition Book

Handbook of High performance liquid chromatography Second E
CRC | 2010 | ISBN: 1574445545 | 715 pages | PDF | 10,7 MB
High performance liquid chromatography (HPLC) is one of the most widespread analytical and preparative scale separation techniques used for both scientific investigations and industrial and biomedical analysis. Now in its second edition, this revised and updated version of the Handbook of HPLC examines the new advances made in this field since the publication of the benchmark first edition twelve years ago. It reports detailed information on fundamental and practical aspects of HPLC related to conventional format and sophisticated novel approaches which have been developed to address a variety of separation problems in different fields.
The latest concepts
New concepts presented in this edition include monolithic columns, bonded stationary phases, micro-HPLC, two-dimensional comprehensive liquid chromatography, gradient elution mode, and capillary electromigration techniques. The book also discusses LC-MS interfaces, nonlinear chromatography, displacement chromatography of peptides and proteins, field-flow fractionation, retention models for ions, and polymer HPLC.
Fundamentals and applications
The first section of the book explores emerging novel aspects of HPLC and related separation methods based on the differential velocity of analytes in a liquid medium under the action of either an electric field (capillary electromigration techniques) or a gravitational field (field-flow fractionation). The section focusing on applications highlights four significant areas in which HPLC is successfully employed: chiral pharmaceutical, environmental analysis, food analysis, and forensic science.Ideal for a widespread audience Explanatory figures and tables supplement the text and clarify difficult concepts. Extensive references provide gateways to more focused study. Suitable for undergraduates or new practitioners interested in improving their knowledge on the current status and future trends of HPLC, the book is also a critical resource for researchers looking for solutions to complex separation problems or those who currently use HPLC either as an analytical or a preparative scale tool.



Liquid Chromatography - Mass Spectrometry: An Introduction Book

Liquid Chromatography Mass Spectrometry An Introduction
Publisher: Wiley | ISBN: 0471498017 | edition 2003 | PDF | 299 pages | 13 mb
First explaining the basic principles of liquid chromatography and mass spectrometry and then discussing the current applications and practical benefits of LC-MS, along with descriptions of the basic instrumentation, this title will prove to be the indispensable reference source for everyone wishing to use this increasingly important tandem technique.
* First book to concentrate on principles of LC-MS
* Explains principles of mass spectrometry and chromatography before moving on to LC-MS
* Describes instrumental aspects of LC-MS
* Discusses current applications of LC-MS and shows benefits of using this technique in practice.


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Handbook of Industrial Chemistry: Organic Chemicals Book.

Handbook of Industrial Chemistry Organic Chemicals

Handbook of Industrial Chemistry Organic Chemicals: The definitive guide for the general chemical analyses of non-petroleum based organic products such as paints, dyes, oils, fats, and waxes. * Chemical tables, formulas, and equations * Covers all of the chemical processes which utilize organic chemicals * Physical properties for the most common organic chemicals Contents: Safety Considerations in Process Industries * Industrial Pollution Prevention and Waste Management * Edible Oils, Fats, and Waxes * Soaps and Detergents * Sugar and Other Sweeteners * Paints, Pigments, and Industrial Coatings * Dyestuffs, Finishing and Dyeing of Textiles * Industrial Fermentation * Pharmaceutical Industry *Agrochemicals * Chemical Explosives * Petroleum Processing and Petrochemicals *Polymers and Plastics.

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Chemical Micro Process Engineering: Fundamentals, Modelling and Reactions Book

Chemical Micro Process Engineering Fundamentals Modelling
Wi-ey | 2004 | ISBN: 3527307419 | 712 pages | PDF | 10,7 MB
Micro process engineering is approaching both academia and industry. With the provision of micro devices and systems by commercial suppliers, one main barrier for using these units has been eliminated. More and more they become familiar, thereby being one facet of the upheaval in chemical industry.
This book focuses on processes rather than on devices: what is ′before′ and ′behind′ micro device fabrication. A comprehensive and detailed overview is given on:A multi–faceted, hierarchic analysis of chemical micro process technology Modelling and simulation of micro reactors Liquid– and liquid/liquid–phase reactions Gas/liquid reactions.


Thursday, January 20, 2011


Publisher: W. H. Freeman | ISBN: 0716730510 | edition 2002 | PDF | 1515 pages | 25,6 mb
With a balance of topic coverage and depth this updated third edition covers the subject of biochemistry, and reflects the advances made in this field since the second edition published in 1981. These advances are incorporated without loss of historical perspective and without obscuring the main goal of the text: to teach the enduring fundamentals of the discipline. Included in the third edition is a completely reorganized part one introducing the flow of information from gene to protein. It emphasizes the growing interrelatedness of molecular biology and biochemistry, and acquaints one with experimental methods of both disciplines. Also included is 150 new problems and a wealth of new material on molecular genetics and cellular processes.


Organic Photovoltaics: Concepts and Realization

Organic Photovoltaics: Concepts and Realization.
Spriger | ISBN: 354000405X | 1 edition | DJVU | 300 pages | 5.6 MB

Achieving efficient solar energy conversion at both large scale and low cost is among the most important technological challenges for the near future. The present volume describes and explains the fundamentals of organic/plastic solar cells in a manner accessible to both researchers and students. It provides a comprehensive analysis of the operational principles underlying several types of solar cells that have absorber layers based on polymer materials and small molecules. It addresses competing approaches, such as polymer solar cells and dye-sensitized cells, while considering the thermodynamic principles within the context of these schemes. Organic Photovoltaics also analyzes in detail the charge-transfer processes in the bulk-heterojunction devices corresponding to the relevant mechanism of carrier generation. Emphasized throughout is the concept of interpenetrating polymer-fullerene networks, due to their high potential for improving power efficiency.


Sunday, January 2, 2011

Organic Experiments by: Louis F. Fieser, Kenneth L. Williamson

Organic Experiments  library.nu #23191
Organic Experiments
By Louis F. Fieser, Kenneth L. Williamson.

  • Publisher: D C Heath & Co
  • Number Of Pages: 645
  • Publication Date: 1992-02
  • ISBN-10 / ASIN: 0669243442
  • ISBN-13 / EAN: 9780669243444
  • Binding: Hardcover.
This book is a must for the beginner to organic chemistry. The first few chapters teach basic techniques such as crystallization, distillation, extraction, TLC, column chromatography and spectroscopy. Experiments include elimination, sustitution and addition reactions, oxidation and reduction, aromatic substitution and elimination, aldehydes and ketones, carboxylic acids, esters, amines, diels-alder, derivatives, photochemistry, natural product chemistry amd biochemistry. Also, gives information on where to locate additional information on chemistry.

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Chiral Separations: Methods and Protocols by: Gerald Gubitz (Editor), Martin G. Schmid (Editor)

Chiral Separations: Methods and Protocols (Methods in Molecular Biology Vol 243)  library.nu #14524
  • Publisher: Humana Press
  • Number Of Pages: 448
  • Publication Date: 2003-12-15
  • Sales Rank: 2783572
  • ISBN / ASIN: 1588291502
  • EAN: 9781588291509
  • Binding: Hardcover
  • Manufacturer: Humana Press
  • Studio: Humana Press
  • Average Rating:
  • Total Reviews:
Book Description:

Prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotographic, gas chromatographic, supercritical fluid chromatographic as well as recent electrochromotographic techniques.


Temperature-Programmed Gas Chromatography by: Leonid M. Blumberg

Temperature-Programmed Gas Chromatography  library.nu #262746
This book provides a comprehensive up-to-date overview of temperature-programmed gas chromatography (GC). The first part of the book introduces the reader to the basics concepts of GC, as well as the key properties of GC columns. The second part describes the mathematical and physical background of GC. In the third part, different aspects in the formation of a chromatogram are discussed, including retention times, peak spacing and peak widths. An invaluable reference for any chromatographer and analytical chemist, it provides all the answers to questions like: * At what temperature does a solute elute in a temperature-programmed analysis? * What is the value of the retention factor of eluting solute? * How wide are the peaks? * How large is the time distance between two peaks? * How do all these parameters depend on the heating rate?

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High-Performance Thin-Layer Chromatography (HPTLC) by: Manmohan Srivastava

High-Performance Thin-Layer Chromatography (HPTLC)  library.nu #260396

The present edited book is the presentation of 18 in-depth national and international contributions from eminent professors, scientists and instrumental chemists from educational institutes, research organizations and industries providing their views on their experience, handling, observation and research outputs on HPTLC, a multi-dimensional instrumentation. The book describes the recent advancements made on TLC which have revolutionized and transformed it into a modern instrumental technique HPTLC. The book addresses different chapters on HPTLC fundamentals: principle, theory, understanding; instrumentation: implementation, optimization, validation, automation and qualitative and quantitative analysis; applications: phytochemical analysis, biomedical analysis, herbal drug quantification, analytical analysis, finger print analysis and potential for hyphenation: HPTLC future to combinatorial approach, HPTLC-MS, HPTLC-FTIR and HPTLC-Scanning Diode Laser. The chapters in the book have been designed in such away that the reader follows each step of the HPTLC in logical order.

Part I Introduction
1 An Overview of HPTLC: A Modern Analytical Technique with
Excellent Potential for Automation, Optimization, Hyphenation,
and Multidimensional Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
MM. Srivastava
Part II Fundamentals, Principle and Advantages of HPTLC
2 Fundamentals and Theory of HPTLC-Based Separation . . . . . . . . . . . . . . 27
Prasad S. Variyar, Suchandra Chatterjee, and Arun Sharma
3 Experimental Aspects and Implementation of HPTLC . . . . . . . . . . . . . . . . 41
Rashmin B. Patel, Mrunali R. Patel, and Bharat G. Batel
4 High-Performance Thin-Layer Chromatography: Excellent
Automation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55
Dilip Charegaonkar
Part III Applications of HPTLC Separation
5 Multidimensional and Multimodal Separations by HPTLC
in Phytochemistry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Lukasz Ciesla and Monika Waksmundzka-Hajnos
6 Stability-Indicating HPTLC Determination of Imatinib Mesylate
in Bulk Drug and Pharmaceutical Dosage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93
P. Musmade, N. Vadera, and G. Subramanian
7 HPTLC Fingerprint Analysis: A Quality Control
for Authentication of Herbal Phytochemicals . . . . . . . . . . . . . . . . . . . . . . . . . 105
Mauji Ram, M.Z. Abdin, M.A. Khan, and Prabhakar Jha
8 HPTLC in Herbal Drug Quantification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117
Machindra J. Chavan, Pravin S. Wakte, and Devanand B. Shinde
9 HPTLC Determination of Artemisinin and Its Derivatives
in Bulk and Pharmaceutical Dosage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
Suraj P. Agarwal and Shipra Ahuja
10 TLC/HPTLC in Biomedical Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151
A. Mohammad and A. Moheman
11 Analytical Aspects of High Performance Thin Layer
Chromatography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179
Gunawan Indrayanto
12 Quantitative Analysis and Validation of Method
Using HPTLC . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
Pinakin Dhandhukia and Janki N. Thakker
13 Quantification of Low Molecular Mass Compounds
Using Thermostated Planar Chromatography . . . . . . . . . . . . . . . . . . . . . . . 223
Paweł K. Zarzycki
Part IV HPTLC and its Future to Combinatorial Approach
14 Basic Principles of Planar Chromatography and Its Potential
for Hyphenated Techniques . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
Tomasz Tuzimski
15 HPTLC–MS Coupling: New Dimension of HPTLC . . . . . . . . . . . . . . . . . 311
Ajai Prakash Gupta and Suphla Gupta
16 TLC/HPTLC with Direct Mass Spectrometric Detection:
A Review of the Progress Achieved in the Last 5 Years . . . . . . . . . . . . . 335
Jurgen Schiller, Beate Fuchs, Kristin Teuber, Ariane Nimptsch,
Kathrin Nimptsch, and Rosmarie Su¨ß
17 Scanning Diode Laser Desorption Thin-Layer Chromatography
Coupled with Atmospheric Pressure Chemical Ionization Mass
Spectrometry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 365
Song Peng, Norman Ahlmann, Michael Edler, and Joachim Franzke
18 HPTLC Hyphenated with FTIR: Principles, Instrumentation
and Qualitative Analysis and Quantitation . . . . . . . . . . . . . . . . . . . . . . . . . . . 385
Claudia Cimpoiu
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 395
xii Contents
List of Contributors
Abdul Moheman Department of Applied Chemistry, Faculty of Engineering and
Technology, Aligarh Muslim University, Aligarh 202002, India
Ajai Prakash Gupta Public Health Engineering Department, IIIM-CSIR, Jammu&
Kashmir, India
Ali Mohammad Department of Applied Chemistry, Faculty of Engineering and
Technology, Aligarh Muslim University, Aligarh 202002, India
Ariane Nimptsch University of Leipzig, Medical Department, Institute of Medical
Physics and Biophysics, Ha¨rtelstr, 16/18, D-04107 Leipzig, Germany
Arun Sharma Food Technology Division, Bhabha Atomic Research Centre,
Mumbai 400085, India
Beate Fuchs University of Leipzig, Medical Department, Institute of Medical
Physics and Biophysics, Ha¨rtelstr, 16/18, D-04107 Leipzig, Germany
Bharat G. Patel A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy,
Sardar Patel University, University of Leipzig Gujarat, Vallabh Vidyanagar 388
120, India
Claudia Cimpoiu Faculty of Chemistry and Chemical Engineering, Babes Bolyari
University, Cluj Napoca, Romania
Devanand B. Shinde Department of Chemical Technology, Dr. Babasaheb
Ambedkar Marathwada University, Aurangabad 431001, India
G. Subramanian Department of Pharmaceutical Quality Assurance, Manipal College
of Pharmaceutical Sciences, Manipal, Karnataka 576104, India
Gunawan Indrayanto Plant Biotechnology Research Group and Assessment Service
Unit Faculty of Pharmacy, Airlangga University, Surabaya 60286, Indonesia
Janki N. Thakker Department of Biotechnology, PD Patel Institute of Applied
Science, Charutar University of Science & Technology, Education Campus
Changa, 388421 Gujarat, India
Joachim Franzke ISAS—Institute for Analytical Sciences, Bunsen-Kirchhoff-
Straße 11, 44139, Otto-Hahn-Straße 6b, 44227 Dortmund, Germany
Jurgen Schiller University of Leipzig, Medical Department, Institute of Medical
Physics and Biophysics, Ha¨rtelstr, 16/18, D-04107 Leipzig, Germany
Kathrin Nimptsch University of Leipzig, Medical Department, Institute of Medical
Physics and Biophysics, Ha¨rtelstr, 16/18, D-04107 Leipzig, Germany
Kristin Teuber University of Leipzig, Medical Department, Institute of Medical
Physics and Biophysics, Ha¨rtelstr, 16/18, D-04107 Leipzig, Germany
Lukasz Ciesla Department of Inorganic Chemistry, Faculty of Pharmacy, Medical
University of Lublin, Lublin, Poland
M.A. Khan Centre for Transgenic Plant Development, Department of Biotechnology,
Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062,
M.Z. Abdin Centre for Transgenic Plant Development, Department of Biotechnology,
Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062,
Machindra J. Chavan Department of Pharmacognosy, Amrutvahini College of
Pharmacy, Sangamner, S.K. Dist-Ahmednagar (M.S) 422 605, India
ManMohan Srivastava Department of Chemistry, Faculty of Science, Dayalbagh
Educational Institute, Dayalbagh, Agra 282110, India
Mauji Ram Centre for Transgenic Plant Development, Department of Biotechnology,
Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062,
Michael Edler ISAS—Institute for Analytical Sciences, Bunsen-Kirchhoff-Straße
11, 44139 Otto-Hahn-Straße 6b, 44227 Dortmund, Germany
Monika Waksmundzka Hajnos Department of Inorganic Chemistry, Faculty of
Pharmacy, Medical University of Lublin, Lublin, Poland
Mrunali R. Patel Indukaka Ipcowala College of Pharmacy, Sardar Patel University,
New Vallabh Vidyanagar, 388 121 Gujarat, India
N. Vadera Department of Pharmaceutical Quality Assurance, Manipal College of
Pharmaceutical Sciences, Manipal, Karnataka 576104, India
Norman Ahlmann ISAS—Institute for Analytical Sciences, Bunsen-Kirchhoff-
Straße 11, 44139 Otto-Hahn-Straße 6b, 44227 Dortmund, Germany
P. Musmade Department of Pharmaceutical Quality Assurance, Manipal College
of Pharmaceutical Sciences, Manipal, Karnataka 576104, India
xiv List of Contributors
Paweł K. Zarzycki Section of Toxicology and Bioanalytics, Koszalin University
of Technology, S ´ niadeckich 2, 75-453 Koszalin, Poland
Pinakin Dhandhukia Ashok and Rita Patel Institute of Integrated Study &
Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar, 388
121 Gujarat, India
Prabhakar Jha Department of Botany, Faculty of Science, Jamia Hamdard,
Hamdard Nagar, New Delhi 110062, India
Prasad S. Variyar Food Technology Division, Bhabha Atomic Research Centre,
Mumbai 400085, India
Pravin S. Wakte Department of Chemical Technology, Dr. Babasaheb Ambedkar
Marathwada University, Aurangabad 431 001 (M.S), India
Rashmin B. Patel A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy,
Sardar Patel University, Vallabh Vidyanagar, 388 120 Gujarat, India
Rosmarie Su¨ß University of Leipzig, Medical Department, Institute of Medical
Physics and Biophysics, Ha¨rtelstr, 16/18, D-04107 Leipzig, Germany
Shipra Ahuja Department of Pharmaceutics, Jamia Hamdard University, Hamdard
Nagar, New Delhi 110062, India
Song Peng ISAS—Institute for Analytical Sciences, Bunsen-Kirchhoff-Straße 11,
44139 Otto-Hahn-Straße 6b, 44227 Dortmund, Germany
Tomasz Tuzimski Department of Physical Chemistry, Faculty of Pharmacy,
Medical University of Lublin, Lublin, Poland.


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Ion-Pair Chromatography and Related Techniques (Analytical Chemistry) by: Teresa Cecchi.

Ion-Pair Chromatography and Related Techniques (Analytical Chemistry)  library.nu #255635

Ion-Pair Chromatography (IPC) is a rapidly evolving method for difficult analyses of organic and inorganic ions and ionogenic, neutral, and zwitterionic compounds. The possibilities for this technology continue to grow as novel ion-pair reagents and strategies are introduced at an accelerated level. Compensating for a dearth in the literature, Ion-Pair Chromatography and Related Techniques details the basics and the evolution of this established and easily tunable technique and explains its influence on similar methods. Theoretical modeling to application Providing a thorough exploration of the multiplicity of interactions involved in an IPC system, this book emphasizes the progress from theoretical modeling to application. It explores the practical potential of IPC in the life science, medicine, pharmacology, forensic, food, and environmental sectors. It examines the upgrade of column technology and instrumentation to improve data quality and to increase sample throughput. The book also compares IPC to other instrumental methods of analysis and discusses the rising importance of the ion-pair concept in different analytical techniques. Future endeavors IPC has the potential to have lasting impact in the field of chromatography. Distilling the knowledge gained from preeminent research, this volume is a critical resource that is destined to stimulate future endeavors by separation scientists working in the area of high performance liquid chromatography.
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