Analytical Profiles of Drug Substances

The concept for gathering together and publishing pertinent information on the physical and chemical properties of various official and new drug substances had its origin with the members of the Section on Pharmaceutical Analysis and Quality Control of the Academy of Pharmaceutical Sciences.More than two years of consideration preceded the authorization of this ambitious project by the Executive Committee of the Academy in the Spring of 1970. The immediate and virtually spontaneous enlistment of the first group of contributors to this work attested to its importance and the wisdom of pursuing its publication. By coincidence, the delegates to the sesquicentennial anniversary meeting of the United States Pharmacopeial Convention, Inc., in Washington, D. C . on April 8-1 0, 1970, adopted the following resolution: Whereas widespread interest has been expressed in the inclusion of additional information about physical and chemical properties of drugs recognized in the United States Pharmacopeia Be I t Resolved that the Board of Trustees consider publishing in the Pharmacopeia, or in a companion publication, information on such attributes as solubilities, pH and pK values, spectra and spectrophotometric constants, and stability data, pertaining to pharmacopeial drugs.The U.S.P.C. Board of Trustees unanimously approved the resolution in principle on June 4, 1970 and authorized the Director of Revision t o include in the U S.P. monographs such physical-chemical information as he deemed
proper and also to cooperate with the Academy of Pharmaceutical Sciences to secure the publication of other physical-chemical data.It was my privilege to be the President of the Academy during the period when Analytical Profiles was under consideration. It is my unusual
and unique honor as President of the Academy and Director of U.S.P Revision to assist in the institution and dedication of this first volume. I trust that it will serve immeasurably in providing the scientific community with an authoritative source of information on the properties of many o f our important drug compounds.

Thomas J. Macek
Director of Revision
The United States Pharmacopeia.

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