DOE Handbook Chemical process hazards analysis

Year: 1996

Language: English

Pages: 93

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A Guide to Safe Material and Chemical Handling (Wiley-Scrivener)

A Guide to Safe Material and Chemical Handling (Wiley-Scrivener).

By Nicholas P. Cheremisinoff

• Wiley-Scrivener
• Number Of Pages: 480
• Publication Date: 2010-03-15
• ISBN-10 / ASIN: 0470625821
• ISBN-13 / EAN: 9780470625828

Product Description:

There have been many volumes written that claim to be the most "comprehensive" compendium or on chemical data. These wieldy volumes are often too big and extraneous to be useful to the practicing engineer. This new volume aims to be the most useful "go to" volume for the working engineer, scientist, or chemist who needs quick answers to daily questions about materials or and doesn't want to go on long searches through voluminous tomes or lengthy internet searches. Covering only the most commonly used chemicals in the most important processes in industry,A Guide to Safe Material and Chemical Handling includes industrial chemicals, such as gases, fuels, and , which are not incorporated in most "comprehensive" on materials and chemical properties. Safety plans and procedures that can be implemented by any engineer or plant manager by following the easy, step-by-step instructions in the book are also provided.

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Chemstations CHEMCAD 6.1.4.3059

Chemstations CHEMCAD 6.1.4.3059 | 174 MB

CHEMCAD is an integrated suite of intuitive chemical process engineering software.

CHEMCAD's scalability allows users to purchase add-ons and features as needed for their specific industry and processes. This results in ultimate flexibility and affordability.

The CHEMCAD suite of products includes:

CC-STEADY STATE

Chemical process simulation software that includes libraries of chemical components, thermodynamic methods, and unit operations to allow steady-state simulation of continuous chemical processes from lab scale to full scale.

Ideal for: Users who want to design processes, or rate existing processes, in steady state.

CC-DYNAMICS

Process simulation software that takes steady-state simulations to the next level of fidelity to allow dynamic analysis of flowsheets. The possibilities are endless: operability check-out, PID loop tuning, operator training, even online process control and soft sensor functionality.

Ideal for: Users who want to design or rate dynamic processes.

CC-THERM

Heat exchanger design and rating software available as an add-on or standalone program. CC-THERM makes use of multiple international standards for design and materials to make sizing a heat exchanger faster and more accurate. The program covers shell-and-tube, plate-and-frame, air-cooled, and double-pipe exchangers. Rigorous designs are based on CHEMCAD's foundation of physical property and phase equilibria data.

Ideal for: Users who want to design or vet a design by a vendor of a heat exchanger (single unit at a time), and those who want to rate existing exchangers in new service or perform "what if" calculations.

CC-SAFETY NET

Piping and safety relief network simulation software that is a subset of CC-STEADY STATE (all of CC-SAFETY NET's features are included in CC-STEADY STATE). This program allows rigorous analysis of any piping. It combines the latest in two-phase relief device calculation, rigorous pressure drop calculation, rigorous physical property calculation, and rigorous phase equilibrium calculation to deliver fast, accurate answers.

Ideal for: Users who need to design or rate piping networks or safety relief devices/systems.

CC-FLASH

Physical properties and phase equilibria calculation software that is a subset of the CHEMCAD suite (all of the CHEMCAD suite products include CC-FLASH capabilities). This program allows rigorous calculation of physical properties and phase equilibria (VLE, LLE, VLLE) for pure components and mixtures.

Ideal for: Users who need physical property and phase equilibrium data, as well as users who need property prediction and regression.

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Safety Assessment for Chemical Processes by Jorg Steinbach

John Wiley & Sons | 1998-12-23 | ISBN: 352728852X | 305 pages | PDF | 13.8 Mb

This book combines the author's experience of 15 years of research in the field of chemical safety and 10 years in the chemical industry. It provides newcomers with an easy access to the field and helps practitioners in the chemical industry to answer all questions concerning their daily work with hazardous materials or potentially dangerous chemical plants. The investigation of risks, and preventive measures to be taken to minimize the probability of an accident, as well as its consequences are explained.

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Compatibility of Pharmaceutical Solutions and Contact Materials: Safety Assessments of Extractables and Leachables for Pharmaceutical Products

Compatibility of Pharmaceutical Solutions and Contact Materials: Safety Assessments of Extractables and Leachables for Pharmaceutical Products.

By Dennis Jenke

• Publisher: Wiley-Interscience
• Number Of Pages: 379
• Publication Date: 2009-06-02
• ISBN-10 / ASIN: 0470281766
• ISBN-13 / EAN: 9780470281765

Product Description

This book specifically addresses the safety aspects of compatibility for drugs and their delivery devices and containers. The author deals with issues such as how the leachables impact safety of a therapeutic product and, more importantly, how one ascertains the magnitude of the impact. The book examines the strategies and tactics for performing safety assessments for leachables and extractables and establishes the means for interpreting the results obtained from such assessments. It helps the pharmaceutical industry unify methodology for assessing leachables and extractables safety of drug packaging.

From the Back Cover Compatibility of Pharmaceutical Products and Contact Materials

Dennis Jenke

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Pharmaceutical Suspensions: From Formulation Development to Manufacturing

Pharmaceutical Suspensions: From Formulation Development to Manufacturing.

By Alok K. Kulshreshtha, Onkar N. Singh, G. Michael Wall

• Publisher: Springer
• Number Of Pages: 323
• Publication Date: 2009-10-16
• ISBN-10 / ASIN: 1441910867
• ISBN-13 / EAN: 9781441910868

Product Description:

The suspension dosage form has long been used for poorly soluble active ingredients for various therapeutic indications. Development of stable dispersions over the shelf life of the drug product continues to be a challenge on many fronts.

A good understanding of fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of suspension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, viscometers, particle size analyzers, etc.) must be utilized to properly characterize the suspension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require clinical trials to establish the safety and efficacy of the drug product. All of this development work should culminate into a regulatory filing in accordance with regulatory guidelines. Pharmaceutical Suspensions, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical active dispersed in a suitable vehicle.

After discussing various disperse systems, the theory of disperse systems and commonly used excipients, the remaining chapters in this textbook systematically detail the development of pharmaceutical suspensions, from pre-formulation stage to clinical development, regulatory submission and commercial manufacturing. Additionally, the emerging area of nano-suspensions as applied to pharmaceutical filed is also discussed. Each of the chapters in Pharmaceutical Suspensions was written independently by scientists skilled in their specific areas. Contributing authors represent a cross-sections of scholars from Academic Institutions, Pharmaceutical Industries and Regulatory Agency.

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Wiley Guide to Chemical Incompatibilities, 3rd Edition

Wiley Guide to Chemical Incompatibilities, 3rd Edition.

By Richard P. Pohanish, Stanley A. Greene

• Publisher: Wiley
• Number Of Pages: 1110
• Publication Date: 2009-08-17
• ISBN-10 / ASIN: 0470387637
• ISBN-13 / EAN: 9780470387634

Product Description:

"This book should be a required reference on the laboratory's safety shelf as no where else is so much useful information available in a single volume."

Inside Laboratory Management, on the Second Edition

"...a portable reference on reactive substances to guide all personnel...in charge of the handling, storage, and transportation of chemical materials."

Journal of the American Chemical Society, on the Second Edition

The authoritative resource on dangerous chemical interactions now enlarged, revised, and even more useful.

The term "incompatibilities" describes a wide range of chemical reactions that produce undesirable results in noncontrolled situations: the generation of toxic gases, fire, explosions, corrosive activity, polymerization, ruptured containers, creation of more dangerous compounds, and the like. A portable and easy-to-use reference on reactive substances commonly found in commerce, the Wiley Guide to Chemical Incompatibilities, Third Edition compiles hard-to-find data on over 11,000 chemical compounds, providing chemists, technicians, and engineers a thorough, lightning-quick resource to use during experimental preparation and in the event of an emergency.

More than a revision of the previous edition, this Third Edition has been rewritten and expanded to broaden coverage and improve its usefulness. It contains nearly 9,000 chemical incompatibility profiles and nearly 250 new entries, covering flammability, violent and explosive binary reactions, incompatibilities, and reactions that may result from physical change. Alphabetical organization provides concise incompatibility profiles for thousands of commonly used commercial chemicals, allowing readers to look up a given substance and instantly learn whether it is incompatible with common materials, other chemical substances, structural materials, or personal protective equipment.

New for the Third Edition:

• Chemicals that have the potential to cause disasters
• Chemical formulas and autoignition temperatures
• More flash points, as well as molecular formulas, lower and upper explosive limits, autoignition temperatures, and NFPA®-type (Red) numerical fire codes
• Safety reminders
• All entries keyed by CAS numbers to eliminate possible confusion among synonyms
• Spanish-, French-, and German-language entries for international use
• Revised glossary helps users who may not be chemists with general chemical terms

With thousands of new entries and easy-to-use organization, the Third Edition of the Wiley Guide to Chemical Incompatibilities remains a handy resource for all safety, first-response, and plant management professionals responsible for the handling, storage, and conveyance of chemical materia.

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Pharmaceutical Suspensions: From Formulation Development to Manufacturing

Pharmaceutical Suspensions: From Formulation Development to Manufacturing.

By Alok K. Kulshreshtha, Onkar N. Singh, G. Michael Wall

• Publisher: Springer
• Number Of Pages: 323
• Publication Date: 2009-10-16
• ISBN-10 / ASIN: 1441910867
• ISBN-13 / EAN: 9781441910868

Product Description:

The suspension dosage form has long been used for poorly soluble active ingredients for various therapeutic indications. Development of stable dispersions over the shelf life of the drug product continues to be a challenge on many fronts.

A good understanding of fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of suspension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, viscometers, particle size analyzers, etc.) must be utilized to properly characterize the suspension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require clinical trials to establish the safety and efficacy of the drug product. All of this development work should culminate into a regulatory filing in accordance with regulatory guidelines. Pharmaceutical Suspensions, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical active dispersed in a suitable vehicle.

After discussing various disperse systems, the theory of disperse systems and commonly used excipients, the remaining chapters in this textbook systematically detail the development of pharmaceutical suspensions, from pre-formulation stage to clinical development, regulatory submission and commercial manufacturing. Additionally, the emerging area of nano-suspensions as applied to pharmaceutical filed is also discussed. Each of the chapters in Pharmaceutical Suspensions was written independently by scientists skilled in their specific areas. Contributing authors represent a cross-sections of scholars from Academic Institutions, Pharmaceutical Industries and Regulatory Agency.

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2006 International Fire Code: Softcover Version by International Code Council

2006 International Fire Code: Softcover Version by International Code Council.

Publisher: Cengage Learning | March 6, 2006 | ISBN: 1580012558 | Pages: 434 | PDF | 48.8 MB

The 2006 International Fire Code, coordinated with the 2006 International Building Code, references national standards to comprehensively address fire safety in new and existing buildings. It provides modern, up-to-date fire code, and addresses conditions hazardous to life and property from fire, explosion, handling or use of hazardous materials, and the use and occupancy of buildings and premises. Prescriptive- and performance- based approaches to fire prevention and fire protection systems are emphasized. Topics addressed include fire department access, fire hydrants, automatic sprinkler systems, fire alarm systems, hazardous materials storage and use, and fire safety requirements for new and existing buildings and premises.

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Enclosure Fire Dynamics (Environmental and Energy Engineering Series) by Bjorn Karlsson and James Quintiere

Enclosure Fire Dynamics (Environmental and Energy Engineering Series) by Bjorn Karlsson and James Quintiere.

Publisher: CRC Press | September 28, 1999 | ISBN: 0849313007 | Pages: 336 | PDF | 6 MB

The increasing complexity of technological solutions to both fire safety design issues and fire safety regulations demand higher levels of training and continuing education for fire protection engineers. Historical precedents on how to deal with fire hazards in new or unusual buildings are seldom available, and new performance-based building codes often require mathematical or computer fire modeling. Until now, however, there has been no current, truly comprehensive engineering book that builds an in-depth understanding of the scientific aspects of enclosure fires.

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Physical Properties of Hydrocarbons: Volume 1 + Volume 2, Second Edition by Robert W. Gallant

Physical Properties of Hydrocarbons: Volume 1 + Volume 2, Second Edition by Robert W. Gallant

Publisher: Gulf Professional Publishing | 2 edition (August 29, 1992) | ISBN: 0884150674 | Pages: 259 | PDF | 19.5 MB

Publisher: CRC Press | 2 edition (August 31, 1988) | ISBN: 0872016900 | Pages: 212 | PDF | 26.6 MB

Providing the essential physical property data needed to design and operate oil refineries, petrochemical plants and gas processing facilities, this expanded edition covers the paraffinic hydrocarbons, halogenated hydrocarbons and several oxygenated hydrocarbons, such as alcohols, oxides and glycols. Data on vapor pressure, heat of vaporization, density, surface tension, heat capacity, thermal conductivity, heat of formation and Gibb's free energy of formation are presented in graphical form for each compound. Wherever possible, data have been extended over a wide temperature range. Water solubility, lower explosion limit and upper explosion limit have been added to the tables to assist environmental and safety engineers. SI and metric units are used for all properties except vapor pressure. Temperatures are in centigrade and conversion tables are included.

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Industrial Fire Safety Guidebook

Industrial Fire Safety Guidebook.

By Tatyana Davletshina

• Publisher: William Andrew
• Number Of Pages: 539
• Publication Date: 1999-01-14
• ISBN-10 / ASIN: 0815514204
• ISBN-13 / EAN: 9780815514206

Product Description:

This reference has been written for emergency response personnel, plant safety specialists, and emergency response coordinators. It has been prepared at a practical level to assist both in training safety personnel and to provide technical information that can assist in responding to a hazard material incident that could lead to a fire hazard situation. Considerable information and technical data are given on petroleum based products since these are among the most widely consumed products, however, the reader will find ample information on other chemicals. Fire situations pose one of the most serious problems in an industrial setting, with the potential loss of lives and property, as well as damage to the environment. Proper response by trained personnel, as well as careful preplanning can minimize the risk and damage caused by fire.

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Handbook of Pharmaceutical Excipients (Rowe, Handbook of Pharmaceutical Excipients)

Handbook of Pharmaceutical Excipients (Rowe, Handbook of Pharmaceutical Excipients).

By Raymond C. Rowe, Paul J. Sheskey, Marian E. Quinn

• Publisher: Pharmaceutical Press
• Number Of Pages: 917
• Publication Date: 2009-07-31
• ISBN-10 / ASIN: 0853697922
• ISBN-13 / EAN: 9780853697923

Product Description:

"The Handbook of Pharmaceutical Excipients" is internationally recognised as the authoritative source of information on pharmaceutical excipients. "The Handbook of Pharmaceutical Excipients" is a comprehensive guide to the uses, properties and safety of pharmaceutical excipients and is an essential reference for those involved in the development, production, control or regulation of pharmaceutical preparations. The handbook collects together essential data on the physical properties of excipients as well as providing information on their safe use and potential toxicity. All monographs are also thoroughly cross-referenced and indexed to allow their identification by chemical, non-proprietary or trade names.

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Dust Explosions in the Process Industries, Third Edition

Rolf Eckhoff, "Dust Explosions in the Process Industries, Third Edition."

Gulf Professional Publishing; 3rd edition (June 2003) | English | 0750676027 | 700 pages | PDF | 14.87 MB

Unfortunately, dust explosions are common and costly in a wide array of industries such as petrochemical, food, paper and pharmaceutical. It is imperative that

practical and theoretical knowledge of the origin, development, prevention and mitigation of dust explosions is imparted to the responsible safety manager. The material in this book offers an up to date evaluation of prevalent activities, testing methods, design measures and safe operating techniques.

Also provided is a detailed and comprehensive critique of all the significant phases relating to the hazard and control of a dust explosion. An invaluable reference work for industry, safety consultants and students.

* A completely new chapter on design of electrical equipment to be used in areas containing combustible/explosible dust

* A substantially extended and re-organized final review chapter, containing nearly 400 new literature references from the years 1997-2002

* Extensive cross-referencing from the original chapters 1-7 to the corresponding sections of the expanded review chapter

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Building Facade Maintenance, Repair, and Inspection

Building Facade Maintenance, Repair, and Inspection (ASTM Special Technical Publication) (Astm Special Technical Publication, 1444)

By ASTM International

Publisher: ASTM International | 325 pages | 2004-01-01 | ISBN: 0803134754 | English | PDF | 8.55 MB

Product Description:

This new ASTM publication, combined with ASTM Standard Practice for Periodic Inspection of Building Facades for Unsafe Conditions (E 2270), provide a rational guide for building owners and governing authorities to help ensure the safety of our aging building infrastructure. Written by experts who bring their first hand knowledge and experience to this work, these 24 peer-reviewed papers cover a wide diversity of architecture within North America. Papers are grouped into the following headings: • Purpose and Background to Facade Ordinances • Addressing Historic Buildings • Investigation and Data Collection Techniques • Material and Repair Techniques STP 1444 is a valuable resource for architects, engineers, contractors, and public and private facility owners.

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Rapid Microbiological Methods in the Pharmaceutical Industry

In recent years there has been increased interest in the possibility of rapid microbiological methods offering enhanced potential error detection capabilities. However, these methods raise a number of questions, such as how to validate new methods, will they be accepted by the pharmacopoeias, and, most importantly, how will the regulators respond? Rapid Microbiological Methods in the Pharmaceutical Industry answers these questions and more. Martin Easter and his panel of experts: § Describe the range of rapid microbiological methods and their applications, including practical tips, and their status regarding validation, established use, and regulatory acceptance § Explore the origins of current methods and the current issues facing the requirements of microbiology and its associated test methods § Delineate the challenges involved in seeking better and more pragmatic methods for the assessment of microbial hazards and risks to ensure product and consumer safety The book assists you in applying an effective system to assess the real microbiological hazards and, hence, quantify realistic risks. Additionally, it provides monitoring methods that will deliver meaningful, useful data for effective decision making in manufacturing, quality assurance, and product safety. The expert and authoritative information in Rapid Microbiological Methods in the Pharmaceutical Industry will help you find better solutions to ensuring the microbiological safety of pharmaceutical products.

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Quality Systems and Controls for Pharmaceuticals

Quality Systems and Controls for Pharmaceuticals.

Publisher: Wiley | Pages: 204 | 2008-10-20 | ISBN: 0470056924 | PDF | 1 MB

Quality Systems and Control for Pharmaceuticals is an accessible overview of the highly-regulated area of pharmaceutical manufacture, the production of biomedical materials, and biomedical devices. Introducing the subject in a clear and logical manner it enables the reader to grasp the key concepts of the multidisciplinary area of control science and specifically quality control using industrial and theoretical models.

Taking a multidisciplinary approach to the subject the reader is guided through key topics such as product safety which takes into account aspects of analytical science, statistics, microbiology, biotechnology, engineering, business practice and optimizing models, the law and safeguarding public health, innovation and inventiveness and contemporary best practice.

The author has both industry and academic experience and many ‘best practice’ examples are included throughout the text based on his own industry experience and current practicing industrial pharmacists. This is an invaluable reference for all students of pharmacy who may have little or no familiarity with industrial practice and for those studying BSc chemistry, biomedical sciences, process analytical chemistry and MSc in Industrial Practice.

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Guidelines for Engineering Design for Process Safety

Center for Chemical Process Safety (CCPS) "Guidelines for Engineering Design for Process Safety ".
Wiley-AIChE | 1993-09-01 | ISBN: 0816905657 | 608 pages | PDF | 27.9 MB

Inherently safer plants begin with the initial design. Here is where integrity and reliability can be built in at the lowest cost, and with maximum effectiveness. This book focuses on process safety issues in the design of chemical, petrochemical, and hydrocarbon processing facilities. It discusses how to select designs that can prevent or mitigate the release of flammable or toxic materials, which could lead to a fire, explosion, or environmental damage. All engineers on the design team, the process hazard analysis team, and those who make basic decisions on plant design, will benefit from its comprehensive coverage, its organization, and the extensive references to literature, codes, and standards that accompany each chapter DOWNLOAD LINK: rapidshare

Guidelines for Integrating Process Safety Management, Environment, Safety, Health, and Quality

Guidelines for Integrating Process Safety Management, Environment, Safety, Health, and Quality.

Wiley-AIChE | December 15, 1996 | ISBN-10: 0816906831 | 192 pages | PDF | 7.13 mb

Over the years, companies have developed independent systems for managing process safety, environment, health, safety, and quality. Many aspects of these management systems are similar. Integrating EHS management systems can yield economies and improved system effectiveness. This book explains how integration reduces cost of delivery through a reduction in the number of management program steps and avoidance of redundancy; how it results in more effective programs, since the best practices can be combined into a single process; and how this integration brings a faster, and more cost effective response to new demands.

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Guidelines for Process Safety in Batch Reaction Systems

Guidelines for Process Safety in Batch Reaction Systems.

Wiley-AIChE | September 15, 1999 | ISBN: 0816907803 | 192 pages | PDF | 1 MB

Batch reaction systems pose unique challenges to process safety managers because they do not operate in a steady state. The sequence of processing steps, and frequent start-ups and shutdowns, increase the possibility of human errors and equipment failures. And, since batch plants are often designed for shared use, frequent modification of piping and layout may occur, resulting in complex "management of change" issues. This book identifies the singular concerns of batch reaction systems—including potential sources of unsafe conditions—and provides a "how-to" guide for the practicing engineer in dealing with them by applying appropriate practices to prevent accidents.

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