Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up

Peter J. Harrington

Year: 2011

Edition: 1

Language: English

Pages: 377

Download (pdf, 7.80 MB) Mirrors: [1] [2]

The Art of Process Chemistry

Providing must-have knowledge for the pharmaceutical industry and process chemists in industry, this ready reference offers solutions for saving time and money and supplying -- in a sustainable way -- valuable products. Application-oriented and well structured, each chapter presents successful strategies for the latest modern drugs, showing how to provide very fast bulk quantities of drug candidates. Throughout, the text illustrates how all the key factors are interwoven and dependent on one another in creating optimized methods for optimal products.

Year: 2010

Edition: 1

Language: English

Pages: 298

Download (pdf, 2.07 MB) Mirrors: [1] [2]

Chemistry Books

Introduction to inorganic chemistry
http://archive.org/details/introductiontoin00valerich

Introduction to inorganic chemistry
http://archive.org/details/introductiontoin00valerich

Introduction to inorganic chemistry (1917)
http://archive.org/details/introductiontoi01smitgoog

A_Text_book_of_Inorganic_Chemistry_Volume VII_Part I
http://archive.org/details/textbookofinorga014432mbp

A_Text-Book_Of_Inorganic_Chemistry_Vol-VII_Part_II
http://archive.org/details/textbookofinorga025529mbp

A_Text-Book_Of_Inorganic_Chemistry_Vol-VI_Part_I
http://archive.org/details/textbookofinorga025526mbp

Modern inorganic chemistry
http://archive.org/details/moderninorganicc00melluoft

A text-book of inorganic chemistry
http://archive.org/details/textbooinorg00newtrich

Advanced Organic Chemistry 6th ed.
http://archive.org/details/AdvancedO...Chemistry6thEd

Introduction to organic chemistry
http://archive.org/details/introductiontoor00stodrich

Organic Chemistry
http://archive.org/details/organicchemistry031426mbp

Organic Chemistry
http://archive.org/details/OrganicChemistryVol1

Organic chemistry; or, Chemistry of the carbon compounds
http://archive.org/details/organichem02richrich

Perkin And Kippings Organic Chemistry Part III
http://archive.org/details/perkinandkipping031024mbp

A Text Book Of Organic Chemistry
http://archive.org/details/textbookoforgani028822mbp

Organic Chemistry Review Sheets
http://archive.org/details/OrganicChemRvw1

Organic chemistry
http://archive.org/details/organicchemistry00perkuoft

Organic chemistry (vol 2)
http://archive.org/details/organicchemistry02perkrich

Organic chemical reagents
http://archive.org/details/organicchemicalr00adamuoft

Organic Chemistry (4th Edition) (U-Torrent)
http://cbsebooks.blogspot.com/2012/0...tiongnv64.html

Practical organic and biochemistry
http://archive.org/details/practicalorganic00plimuoft

Basic Principles of Organic Chemistry, 2ed
by John D. Roberts, Marjorie C. Caserio
http://authors.library.caltech.edu/25034/

Micro- and Nano-Transport of Biomolecules
by David Bakewell
http://bookboon.com/en/textbooks/bio...f-biomolecules 

Monk Physical Chemistry
http://archive.org/details/MonkPhysicalChemistry


Physical Chemistry
http://archive.org/details/physicalchemistr029701mbp

Physical Chemistry For Colleges
http://archive.org/details/physicalchemistr029686mbp

An Introduction To Electrochemistry
http://archive.org/details/introductiontoel031801mbp

Introduction To Physical Chemistry
http://archive.org/details/introductiontoph033459mbp

Outlines Of Theoretical Chemistry
http://archive.org/details/outlinesoftheore030729mbp

Tables of physical and chemical constants and some mathematical functions
http://archive.org/details/tablesphysical00kayerich

Introduction to physical chemistry
http://archive.org/details/introductiontop00walkgoog

Introduction To Physical Chemistry
http://archive.org/details/introductiontoph033459mbp

An Introduction To Electrochemistry
http://archive.org/details/introductiontoel031801mbp


Other Books
Molecular electronic structures : an introduction
http://authors.library.caltech.edu/25039/

Organic Chemistry Books

A Small Scale Approach to Organic Laboratory Techniques, 3rd Edition
Donald L. Pavia (Author), Gary M. Lampman (Author), George S. Kriz (Author), Randall G. Engel (Author)
 PDF|1024 pages|Brooks Cole; 3 edition (February 2, 2010)

Featuring new experiments, a new essay, and new coverage of nanotechnology, this organic chemistry laboratory textbook offers a comprehensive treatment of laboratory techniques including small scale and some microscale methods that use standard-scale ("macroscale") glassware and equipment. The book is organized based on essays and topics of current interest and covers a large number of traditional organic reactions and syntheses, as well as experiments with a biological or health science focus. Seven introductory technique-based experiments, thirteen project-based experiments, and sections on green chemistry and biofuels spark students' interest and engage them in the learning process. Instructors may choose to offer Cengage Learning's optional Premium Website, which contains videos on basic organic laboratory techniques.

 Download free PDF bookA Small Scale Approach to Organic Laboratory Techniques, 3rd Edition

Download Link: 

Depositfiles       

Experimental Organic Chemistry- A Miniscale and Microscale Approach 5th - Gilbert, Martin

PDF|John C. Gilbert (Author), Stephen F. Martin (Author)|960 pages|Brooks Cole; 5 edition (January 19, 2010)

Providing even more emphasis on inquiry-based learning, a new green experiment, and more than a dozen new discovery experiments, this Fifth Edition of Gilbert and Martin's proven EXPERIMENTAL ORGANIC CHEMISTRY contains procedures for both miniscale (also known as small scale) and microscale users. The manual first provides an early focus on equipment, record keeping, and safety in the laboratory, then walks students step by step through the laboratory techniques they need to perform the book's experiments with confidence. Chapters show students how to use the book's techniques to synthesize compounds and analyze their properties, complete multi-step syntheses of organic compounds, and solve structures of unknown compounds. A bioorganic experiment in Chapter 24 reflects the increasing emphasis on bioorganic chemistry in the course and gives students an opportunity to accomplish a mechanistically interesting and synthetically important coupling of two a-amino acids to produce a dipeptide.

 Download free PDF bookExperimental Organic Chemistry: A Miniscale and Microscale Approach

Download Link: 

Depositfiles       

Organic Chemistry: An Intermediate Text, 2nd Edition| PDF
 Robert V. Hoffman| 496 pages |September 2004



Ideal for those who have previously studies organic chemistry but not in great depth and with little exposure to organic chemistry in a formal sense. This text aims to bridge the gap between introductory-level instruction and more advanced graduate-level texts, reviewing the basics as well as presenting the more advanced ideas that are currently of importance in organic chemistry.
* Provides students with the organic chemistry background required to succeed in advanced courses.
* Practice problems included at the end of each chapter.

 Download free PDF book Organic Chemistry: An Intermediate Text, 2nd Edition

Download Link: 

 Depositfiles       

Organic Chemistry 8th ed. - F. Carey, R. Giuliano (McGraw-Hill, 2011)| PDF

Throughout all eight editions, Organic Chemistry has been designed to meet the needs of the "mainstream," two-semester, undergraduate organic chemistry course. This best-selling text gives students a solid understanding of organic chemistry by stressing how fundamental reaction mechanisms function and reactions occur.

Download Link: 

Depositfiles

Organic Chemistry 2nd Edition by Hornback Solutions Guide

Written by Joseph Hornback, this manual contains detailed solutions to all text problems.

Download Link: 

Depositfiles

Organic Chemistry 2nd Edition by Hornback

ORGANIC CHEMISTRY, Second Edition - the first mechanistic-oriented book written at a level that organic chemistry students will understand! Specifically, the focus on mechanisms is a unifying theme, rather then just an organizing principle. Organizationally mainstream, it is unique in bringing in mechanisms as a unifying principle, and reactions are organized by mechanism type not by functional groups. And now, text/media integration has never been so seamless with the introduction of Organic ChemistryNow for ORGANIC CHEMISTRY, Second Edition.
Download Link: 

Depositfiles

Understanding the Principles of Organic Chemistry: A Laboratory Experience

Class-tested by thousands of students and using simple equipment and green chemistry ideas, UNDERSTANDING THE PRINCIPLES OF ORGANIC CHEMISTRY: A LABORATORY COURSE includes 36 experiments that introduce traditional, as well as recently developed synthetic methods. Offering up-to-date and novel experiments not found in other lab manuals, this innovative book focuses on safety, gives students practice in the basic techniques used in the organic lab, and includes microscale experiments, many drawn from the recent literature. An Online Instructor's Manual available on the book's instructor's companion website includes helpful information, including instructors' notes, pre-lab meeting notes, experiment completion times, answers to end-of-experiment questions, video clips of techniques, and more.

Download Link: 

Depositfiles

T. W. Graham Solomons and Craig Fryhle, “Organic Chemistry” 10 edition

The Tenth Edition of Organic Chemistry continues Solomons/Fryhle’s tradition of excellence in teaching and preparing students for success in the organic classroom and beyond. In the Tenth Edition, virtually every aspect of the teaching and learning solution has been revisited and redesigned to assist students in comprehending the fundamentals of organic chemistry. The authors’ thoroughly explain and illustrate each new idea when it is first introduced and then reinforce the new idea or concept by having students work related problems.

Download Link: 

Depositfiles 

Organic Chemistry SIXTH EDITION,William H. Brown , Christopher S. Foote , Brent L. Iverson , Eric Anslyn | PDF

Renowned for its unified mechanistic themes, emphasis on biological examples, use of applied problems from the pharmaceutical field, and unrivaled full-color visuals, ORGANIC CHEMISTRY, Sixth Edition, delivers cutting-edge coverage packed with reader-friendly features. Offering a clear presentation, the book offsets reaction mechanisms in a stepwise fashion and emphasizes similarities between related mechanisms, using just four different characteristics: breaking a bond, making a new bond, adding a proton and taking a proton away. Numerous resources assist in mastery of key concepts and problem-solving skills, including a running margin glossary, a mini in-text study guide, medicinal chemistry problems, unique roadmap problems, and more in-chapter examples than any other book.

 

Download Link: 

Depositfiles 

Organic Chemistry: Structure and Function, 6th Edition
English | PDF | 1203 Pages | 

With authors who are both accomplished researchers and educators, Vollhardt and Schore’s Organic Chemistry is proven effective for making contemporary organic chemistry accessible, introducing cutting-edge research in a fresh, student-friendly way. A wealth of unique study tools help students organize and understand the substantial information presented in this course.

And in the sixth edition, the themes of understanding reactivity, mechanisms, and synthetic analysis to apply chemical concepts to realistic situations has been strengthened. New applications of organic chemistry in the life sciences, industrial practices, green chemistry, and environmental monitoring and clean-up are incorporated. This edition includes more than 100 new or substantially revised problems, including new problems on synthesis and green chemistry, and new “challenging” problems.

Download Link: 

Depositfiles 

Synthetic Strategies in Chemistry

Book: Synthetic Strategies in Chemistry

Author: B. Viswanathan
Publication Year: 2008

Description:

Introduction to synthetic strategies in chemistry, synthetic methods based on activating the reactant, methods based on activating the reacting substance, synthesis of materials based on solubility principle, sol-gel techniques, template based synthesis, micro-emulsion techniques, synthesis by solid state decomposition, newer synthetic strategies for nano materials, the role of synthesis in materials technology, electrochemical synthesis, catalytic and non catalytic, synthesis strategies – from laboratory to industry, synthesis of chemicals from CO2, carbohydrates to chemicals, some conceptual developments in synthesis in chemistry, computational basics underlying the synthetic strategies.

Download Links:

Download Link 1

Download Link 2

Safety-Scale Laboratory Experiments for Chemistry

Author(s):	Spencer L. Seager
Publisher:

Date:	2010-06-09	Format:	PDF	Language:	English	ISBN10:	053873454X
Pages:	544	OCR:		Quality:		ISBN13:	9780538734547

http://lumfile.com/a7ohnq3t5vxh/053873454X_Laboratory.pdf.html

Chemistry of Drugs (New Chemistry)

uthor(s):	David E. Newton
Publisher:	Facts on File (J)

Date:	2007-08	Format:	pdf	Language:	English	ISBN10:	081605276X
Pages:	192	OCR:		Quality:		ISBN13:	9780816052769

Download Link:
http://uploaded.net/file/b0tvgtui

Mathematical Modeling Approaches for Optimization of Chemical Processes

Author(s):	Gabriela Corsano
Publisher:

Date:	2009-02-28	Format:	PDF	Language:	English	ISBN10:	1604569425
Pages:	91	OCR:		Quality:		ISBN13:	9781604569421

Download Link:
http://uploaded.net/file/9ganv3q1

Handbook of Organic Solvent Properties

Author(s):	Ian Smallwood
Publisher:	Butterworth-Heinemann

Date:	1996-04-12	Format:	PDF	Language:	English	ISBN10:	0340645784
Pages:	306	OCR:		Quality:		ISBN13:	9780340645789

Download

http://uploaded.net/file/im22qkjw

Industrial Organic Chemistry, Hans-Jurgen Arpe, Stephen Hawkins

'Ideal for getting an overview of applied organic chemistry'

This bestselling standard, now in its 3rd completely revised English edition, is an excellent source of technological and economic information on the most important precursors and intermediates used in the chemical industry. Right and left columns containing synopsis of the main text and statistical data, and numerous fold-out flow diagrams ensure optimal didactic presentation of complex chemical processes.
The translation into eight languages, the four German and three English editions clearly evidence the popularity of this book.

Download Link: 

Depositfiles

Chemistry The Practical Science

From core concepts to current applications, Chemistry: The Practical Science promotes an interrogative approach that develops effective problem solvers and critical thinkers for today's world. Using the text and its pedagogical features as a model, students learn to appreciate the role of questioning in the process of chemistry and begin to think like chemists. In addition, applications woven throughout the narrative, examples, and exercises present core chemical concepts in the context of everyday life. This integrated approach encourages curiosity and demonstrates the relevance of chemistry and its uses in students' lives, their future careers, and their world. Chemistry introduces new topics as an instructor would in the classroom. The authors' approach to problem solving prompts students to begin by asking questions about the topic, think critically to arrive at a solution, evaluate their answers, and uncover related information about the concepts being explored. A dynamic art program, comprehensive end-of-chapter materials, and powerful technology resources complete this innovative textbook program.

 

Download Link: 

Depositfiles 

 

The Molecular World: Separation, Purification and Identification

This book looks at the common techniques used to prepare, purify and indentify chemicals. Topics including distillation, recrystallisation, chromatography, elemental analysis, atomic absorption spectroscopy and mass spectrometry are discussed, and are illustrated on video on the accompanying CD-ROMs. Infrared and nuclear magnetic resonance spectroscopy are covered entirely through multi-media, with animations and virtual experiments. The reader is provided with examples for interpretation, and can draw in the structures using the software provided. There is also a set of interactive self-assessment questions. In all, the multi-media software suite comprises more than twelve hours of material. Separation, Purification and Identification concludes with a Case Study on Forensic Science, in which illustrations of criminal cases where spectroscopic techniques provided evidence are given. The Molecular World series provides an integrated introduction to all branches of chemistry for both students wishing to specialise and those wishing to gain a broad understanding of chemistry and its relevance to the everyday world and to other areas of science. 

 

Download Link: 

Depositfiles 

Macroscale and Microscale Organic Experiments, 6th Edition

  The market leader for the full-year organic laboratory, this manual derives many experiments and procedures from the classic Feiser lab text, giving it an unsurpassed reputation for solid, authoritative content. The book includes new experiments that stress greener chemistry, updated NMR spectra, and a Premium Website that includes glassware-specific videos with pre-lab exercises. Offering a flexible mix of macroscale and microscale options for most experiments, this proven manual allows users to save on the purchase and disposal of expensive, sometimes hazardous organic chemicals. Macroscale versions can be used for less costly experiments, giving readers experience working with conventionally sized glassware.

Download Link: 

Depositfiles

Understanding the Principles of Organic Chemistry: A Laboratory Experience

Class-tested by thousands of students and using simple equipment and green chemistry ideas, UNDERSTANDING THE PRINCIPLES OF ORGANIC CHEMISTRY: A LABORATORY COURSE includes 36 experiments that introduce traditional, as well as recently developed synthetic methods. Offering up-to-date and novel experiments not found in other lab manuals, this innovative book focuses on safety, gives students practice in the basic techniques used in the organic lab, and includes microscale experiments, many drawn from the recent literature. An Online Instructor's Manual available on the book's instructor's companion website includes helpful information, including instructors' notes, pre-lab meeting notes, experiment completion times, answers to end-of-experiment questions, video clips of techniques, and more.

Download Link: 

Depositfiles

Organic Chemistry 8th ed. - F. Carey, R. Giuliano (McGraw-Hill, 2011)| PDF

Throughout all eight editions, Organic Chemistry has been designed to meet the needs of the "mainstream," two-semester, undergraduate organic chemistry course. This best-selling text gives students a solid understanding of organic chemistry by stressing how fundamental reaction mechanisms function and reactions occur.

Download Link: 

Depositfile

Experimental Organic Chemistry- A Miniscale and Microscale Approach 5th - Gilbert, Martin

PDF|John C. Gilbert (Author), Stephen F. Martin (Author)|960 pages|Brooks Cole; 5 edition (January 19, 2010)

Providing even more emphasis on inquiry-based learning, a new green experiment, and more than a dozen new discovery experiments, this Fifth Edition of Gilbert and Martin's proven EXPERIMENTAL ORGANIC CHEMISTRY contains procedures for both miniscale (also known as small scale) and microscale users. The manual first provides an early focus on equipment, record keeping, and safety in the laboratory, then walks students step by step through the laboratory techniques they need to perform the book's experiments with confidence. Chapters show students how to use the book's techniques to synthesize compounds and analyze their properties, complete multi-step syntheses of organic compounds, and solve structures of unknown compounds. A bioorganic experiment in Chapter 24 reflects the increasing emphasis on bioorganic chemistry in the course and gives students an opportunity to accomplish a mechanistically interesting and synthetically important coupling of two a-amino acids to produce a dipeptide.

 Download free PDF bookExperimental Organic Chemistry: A Miniscale and Microscale Approach

Download Link: 

   Depositfiles

Organic Chemistry: An Intermediate Text, 2nd Edition

Organic Chemistry: An Intermediate Text, 2nd Edition| PDF
 Robert V. Hoffman| 496 pages |September 2004

Ideal for those who have previously studies organic chemistry but not in great depth and with little exposure to organic chemistry in a formal sense. This text aims to bridge the gap between introductory-level instruction and more advanced graduate-level texts, reviewing the basics as well as presenting the more advanced ideas that are currently of importance in organic chemistry.
* Provides students with the organic chemistry background required to succeed in advanced courses.
* Practice problems included at the end of each chapter.

 Download free PDF book Organic Chemistry: An Intermediate Text, 2nd Edition

Download Link: 

Depositfiles

Macroscale and Microscale Organic Experiments

"Macroscale and Microscale Organic Experiments" by Kenneth L. Williamson, Katherine M. Masters
Sixth Edition
Brooks/Cole, Cengage Learning | 2011 | ISBN: 0538733330 9780538733335 | 818 pages | PDF | 45 MB

This manual derives many experiments and procedures from the classic Feiser lab text, giving it an unsurpassed reputation for solid, authoritative content. The book includes new experiments that stress greener chemistry, updated NMR spectra, and a Premium Website that includes glassware-specific videos with pre-lab exercises.

Offering a flexible mix of macroscale and microscale options for most experiments, this proven manual allows users to save on the purchase and disposal of expensive, sometimes hazardous organic chemicals. Macroscale versions can be used for less costly experiments, giving readers experience working with conventionally sized glassware.

Contents
Preface
Organic Experiments and Waste Disposal
1: Introduction
2: Laboratory Safety, Courtesy, and Waste Disposal
Techniques
3: Melting Points and Boiling Points
4: Recrystallization
5: Distillation
6: Steam Distillation, Vacuum Distillation, and Sublimation
7: Extraction
8: Thin-Layer Chromatography: Analyzing Analgesics and Isolating Lycopene from Tomato Paste
9: Column Chromatography: Fluorenone, Cholesteryl Acetate, Acetylferrocene, and Plant Pigments
10: Gas Chromatography: Analyzing Alkene Isomers
11: Infrared Spectroscopy
12: Nuclear Magnetic Resonance Spectroscopy
13: Mass Spectrometry
14: Ultraviolet Spectroscopy, Refractive Indices, and Qualitatibe Instrumental Organic Analysis
15: Computational Chemistry
The Synthetic Experiments
16: The SN2 Reaction: 1-Bromobutane
17: Nucleophilic Substitution Reactions of Alkyl Halides
18: Radical Initiated Chlorination of 1-Chlorobutane
19: Alkenes from Alcohols: Cyclohexene from Cyclohexanol
20: Bromination and Debromination: Purification of Cholesterol
21: Dichlorocarbene
Oxidation and Reduction
22: Oxidation: Cyclohexanol to Cyclohexanone; Cyclohexanone to Adipic Acid
23: The Cannizzaro Reaction: Simultaneous Synthesis of an Alcohol and an Acid in the Absence of Solvent
24: Oxidative Coupling of Alkynes: 2,7-DimethyI-3,5-octadiyn- 2,7-diol
25: Catalytic Hydrogenation
26: Sodium Borohydride Reduction of2-Methylcyclohexanone: A Problem in Conformational Analysis
27: Epoxidation of Cholesterol
Aromatic Substitution and Elimination
28: Nitration of Methyl Benzoate
29: Friedel—Crafts Alkylation of Benzene and Dimethoxybenzene, Host-Guest Chemistry
30: Alkylation of Mesitylene
31: The Friedel—Crafts Reaction: Anthraquinone and Anthracene
32: Friedel—Crafts Acylation of Ferrocene: Acetylferrocene
33: Reactions of Triphenylmethyl Carbocation, Carbanion, and Radical
34: 1,2,3,4-Tetraphenylnaphthalene via Benzyne
35: Triptycene via Benzyne
Reactions of Aldehydes and Ketones
36: Aldehydes and Ketones
37: Dibenzalacetone by the Aldol Condensation
38: Grignard Synthesis of Triphenylmethanol and Benzoic Acid
39: The Wittig and Wittig-Horner Reactions
Reactions of Carboxylic Acids, Esters, and Amines
40: Esterification and Hydrolysis
41: Acetylsalicylic Acid(Aspirin)
42: Malomc Ester of a Barbiturate
43: Amines
44: The Sandmeyer Reaction: 1-Bromo-4-chlorobenzene, 2-lodobenzoic Acid, and 4-Chlorotoluene
45: Synthesis and Bioassay of Sulfanilamide and Derivatives
46: Dyes and Dyeingl
47: Martius Yellow
The Diels—Alder and Related Reactions
48: Diels—Alder Reaction
49: Ferrocene [Bis(cyclopentadienyl)iron]
50: A Diels—Alder ReactionPuzzle: The Reaction of 2,4-Hexadien-1-ol with Maleic Anhydride
51: Tetraphenylcyclopentadienone
52: Hexaphenylbenzene and Dimethyl TetraphenyIphthalate
Derivatives of 1,2-Diphenylethane: A Multistep Synthesis
53: The Benzoin Condensation: Catalysis by the Cyanide Ion and Thiamine
54: Nitric Acid Oxidation; Preparation of Benzil from Benzoin, and Synthesis of a Heterocycle: Diphenylquinoxaline
55: The Borohydride Reductionof a Ketone: Hydrobenzoinfrom Benzil
65: Biosynthesis of Ethanol and Enzymatic Reactions
56: The Synthesis of 2,2-Dimethy 1-1,5-Dioxolane, The Acetonide Derivative of a Vicinal Diol
57: 1,4-Addition: Reductive Acetylation of Benzil
58: The Synthesis of an Alkyne from an Alkene, Bromination and Dehydrobromination: Stilbene and Diphenylacetylene
59: The Perkin Reaction: Synthesis of D-Phenylcinnamic Acid and Its Decarboxylation to cis-Stilbene
60: Multicomponent Reactions: The Aqueous Passerini Reaction
Photochemistry
61: Chemiluminescence: Syntheses of Cyalume and Luminol
62: Photochemistry: The Synthesis of Benzopinacol
Natural Product Chemistry and Biochemistry
63: Carbohydrates and Sweeteners
64: Virstatin, a Possible Treatment for Cholera
65: Biosynthesis of Ethanol and Enzymatic Reactions
66: The Synthesis of Natural Products: The Sex Attractan tof the Cockroach and Camphor
67: Polymers: Synthesis and Recycling
68: Searching the Chemical Literature
Index

with TOC BookMarkLinks

Download Link:

DepositF • | • RGator

UlNet • | • SiBi • | • TuBi