Edited by Peter Mikus, ISBN 978-953-51-0657-9, Hard cover, 197 pages, Publisher: InTech, Published: August 29, 2012 under CC BY 3.0 license
DOI: 10.5772/3321
DOI: 10.5772/3321
The scientific monograph by the author Peter
Mikus entitled "Chiral Capillary Electrophoresis in Current
Pharmaceutical and Biomedical Analysis" provides a comprehensive view on
the advanced capillary electrophoresis techniques aimed to current
chiral bioanalysis. The advances in the chiral electrophoresis
analytical approaches are divided and theoretically described in three
sections involving (i) advanced chiral separations for the optimization
of chiral resolution (separation mechanisms; electrophoresis techniques
in capillary and microchip format; electrophoretic modes such as ITP,
CZE/EKC, CEC; chiral additives / pseudophases / phases), (ii) advanced
sample preparation for the on-line preconcentration, sample clean-up and
analyte derivatization (implementation of electrophoretic effects such
as stacking; non-electrophoretic effects such as SPE, chromatography,
dialysis; combinations of these effects; multidimensional CE systems;
instrumental schemes), (iii) advanced combinations of detection and
electrophoresis for the optimization in qualitative and quantitative
evaluation (the most important universal as well as selective detection
approaches such as absorption and fluorescence spectrophotometry,
electrochemical detection, mass spectrometry vs. (i) and/or (ii)). Real
analytical potential (benefits and limitations) of these advanced
analytical approaches is emphasized by selected performance parameters
of the methods and illustrated by many current practical applications
including chiral analyses of drugs, their (bio)degradation products and
biomarkers in pharmaceutical and biological matrices. The author wishes
the readers many inspirations in the creation of new innovative
approaches in the field of advanced chiral electrophoresis techniques
with the aim to overcome capabilities of the current analytical
techniques.
1 comment:
Thank you........................
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