Nitroazoles: Synthesis, Structure and Applications

Nitroazoles: Synthesis, Structure and Applications (Topics in Applied Chemistry).

By Lyudmila Larina, Valentin Lopyrev

• Publisher: Springer
• Number Of Pages: 441
• Publication Date: 2009-09-23
• ISBN-10 / ASIN: 0387980695
• ISBN-13 / EAN: 9780387980690

Product Description:

The monograph gives an exhaustive and systematic description of the methods of synthesis, application, structure and properties of nitroazoles perspective medicines, universal bases in peptide nucleic acids, agrochemicals, and components of high-energy materials. All five-membered nitroderivatives of azoles - pyrazoles, imidazoles, triazoles, tetrazoles, oxazoles, isoxazoles, oxadiazoles, thiazoles, isothiazoles, thiadiazoles, and their benzanalogs - indazoles, benzimidazoles, benzoxazoles, benzisoxazoles, benzoxadiazoles, benzothiazoles, benzoisothiazoles, benzothiadiazoles, benzotriazoles are discussed in the book. Special attention is paid to the nitroimidazole derivatives many of which are well-known drugs and hypoxic cell radiosensitizers (azomycine, metronidazole, misonidazole, tinidazole, dimetridazole, ipronidazole, carnidazole and etc). The critical evaluation of a large body of the information on nitroazoles investigations by physicochemical methods (NMR, NQR, ESR, UV, IR- specrtoscopy, X-ray, mass-spectrometry, polarography, dipole moments and others methods) is presented here.

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